公开(公告)号：US20170209545A1

公开(公告)日：2017-07-27

申请号：US15505124

申请日：2015-08-21

申请人： Douglas S. WATSON ,  Allison C. ORTIGOSA ,  Mark C. SLEEVI ,  Kathryn M. STORY ,  Merck Sharp & Dohme Corp.

发明人： Douglas S. Watson ,  Allison C. Ortigosa ,  Mark C. Sleevi ,  Kathryn M. Story

IPC分类号： A61K38/28 ,  A61K47/10 ,  A61K9/14 ,  A61K47/02

CPC分类号： A61K38/28 ,  A61K9/143 ,  A61K9/145 ,  A61K47/02 ,  A61K47/10 ,  C07K14/62

摘要： A method for crystallizing insulin or insulin analogs under alkaline conditions in the presence of zinc, purifying the crystals by filtering through a filter, and drying the crystals captured on the filter to produce crystalline insulin or insulin analog compositions is described. Method has been exemplified with insulin lispro.

公开(公告)号：US10124040B2

公开(公告)日：2018-11-13

申请号：US15505124

申请日：2015-08-21

申请人： Merck Sharp & Dohme Corp. ,  Douglas S. Watson ,  Allison C. Ortigosa ,  Mark C. Sleevi ,  Kathryn M. Story

发明人： Douglas S. Watson ,  Allison C. Ortigosa ,  Mark C. Sleevi ,  Kathryn M. Story

IPC分类号： A61K38/28 ,  A61K47/02 ,  A61K47/10 ,  A61K9/14 ,  C07K14/62

摘要： A method for crystallizing insulin or insulin analogs under alkaline conditions in the presence of zinc, purifying the crystals by filtering through a filter, and drying the crystals captured on the filter to produce crystalline insulin or insulin analog compositions is described. Method has been exemplified with insulin lispro.