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公开(公告)号:US20220152111A1
公开(公告)日:2022-05-19
申请号:US17586698
申请日:2022-01-27
发明人: Rainer Ludwig KNAUS , Katy Rebecca NEWTON , Juan VERA , Ann LEEN , Cliona ROONEY , John R. WILSON
IPC分类号: A61K35/17 , C12M1/04 , A61K39/12 , C12N5/0783 , A61K39/245 , A61K39/235 , C12N7/00
摘要: An in vitro expansion process for rapid expansion of antigen specific T cells, such as allogeneic antigen specific cells comprising the steps culturing in a gas permeable vessel a population of PBMCs (such as allogeneic PBMCs) in the presence of antigen, for example a peptide or peptide mix relevant to a target antigen(s), in the presence of an exogenous cytokine characterized in that the expansion to provide the desired population of T cells is 14 days or less, for example 9, 10, 11 or 12 days, such as 10 days. The disclosure also extends to T cell populations generated by and obtained from the method and the use of same in therapy.