公开(公告)号：US09089572B2

公开(公告)日：2015-07-28

申请号：US12321463

申请日：2009-01-20

申请人： Steven J. Brown ,  Tsui-Fen Chou ,  Raymond Deshaies ,  Amanda C. Jones ,  Hugh Rosen ,  Brian M. Stoltz

发明人： Steven J. Brown ,  Tsui-Fen Chou ,  Raymond Deshaies ,  Amanda C. Jones ,  Hugh Rosen ,  Brian M. Stoltz

IPC分类号： A61K31/519

CPC分类号： A61K31/519

摘要： One aspect of the invention relates to compounds that inhibit the activity of p97, such as by binding covalently to a cysteine residue in the active site. In certain embodiments, the invention relates to the treatment of disease, such as cancer, comprising administering a compound of the invention.

公开(公告)号：US20090253717A1

公开(公告)日：2009-10-08

申请号：US12321463

申请日：2009-01-20

申请人： Steven J. Brown ,  Tsui-Fen Chou ,  Raymond Deshaies ,  Amanda C. Jones ,  Hugh Rosen ,  Brian M. Stoltz

发明人： Steven J. Brown ,  Tsui-Fen Chou ,  Raymond Deshaies ,  Amanda C. Jones ,  Hugh Rosen ,  Brian M. Stoltz

IPC分类号： A61K31/519 ,  A61P35/00

CPC分类号： A61K31/519

摘要： One aspect of the invention relates to compounds that inhibit the activity of p97, such as by binding covalently to a cysteine residue in the active site. In certain embodiments, the invention relates to the treatment of disease, such as cancer, comprising administering a compound of the invention.

摘要翻译： 本发明的一个方面涉及抑制p97活性的化合物，例如通过与活性位点中的半胱氨酸残基共价结合。 在某些实施方案中，本发明涉及疾病如癌症的治疗，其包括施用本发明的化合物。