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    CGRP RECEPTOR ANTAGONISTS
    1.
    发明申请
    CGRP RECEPTOR ANTAGONISTS 审中-公开
    CGRP受体拮抗剂

    公开(公告)号：US20140275017A1

    公开(公告)日：2014-09-18

    申请号：US14294310

    申请日：2014-06-03

    申请人： Craig A. Stump ,  Amy G. Quigley ,  Cory R. Theberge ,  Michael R. Wood

    发明人： Craig A. Stump ,  Amy G. Quigley ,  Cory R. Theberge ,  Michael R. Wood

    IPC分类号： C07D471/20 ,  C07D471/10 ,  C07D519/00

    CPC分类号： C07D471/20 ,  C07D471/10 ,  C07D519/00

    摘要： Compounds of Formula I: (wherein variables A1, A2, A3, ring-B, m, n, J, E1, E2, E3, R5, RPG and Y are as described herein), which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and the use of these compounds and compositions in the prevention or treatment of diseases in which CGRP receptors are involved.

    摘要翻译： 式I化合物（其中变量A1，A2，A3，环-B，m，n，J，E1，E2，E3，R5，RPG和Y如本文所述），其可用作CGRP受体的拮抗剂， 并且可用于治疗或预防涉及CGRP受体的疾病，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含式（I）化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。

    CGRP receptor antagonists
    2.
    发明授权
    CGRP receptor antagonists 有权
    CGRP受体拮抗剂

    公开(公告)号：US08778957B2

    公开(公告)日：2014-07-15

    申请号：US13256354

    申请日：2010-03-08

    申请人： Craig A. Stump ,  Amy G. Quigley

    发明人： Craig A. Stump ,  Amy G. Quigley

    IPC分类号： C07D471/20 ,  A61K31/437

    CPC分类号： C07D471/20 ,  C07D471/10 ,  C07D519/00

    摘要： Compounds of Formula (I) (wherein variables A1, A2, A3, ring-B, m, n, J, E1, E2, E3, R5, RPG and Y are as described herein), which are useful as antagonists of CGRP receptors, and useful in the treatment or prevention of diseases in which CGRP receptors are involved, such as headache, and in particular migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and the use of these compounds and compositions in the prevention or treatment of diseases in which CGRP receptors are involved.

    摘要翻译： 式（I）化合物（其中变量A1，A2，A3，环-B，m，n，J，E1，E2，E3，R5，RPG和Y如本文所述），其可用作CGRP受体的拮抗剂 并且可用于治疗或预防涉及CGRP受体的疾病，例如头痛，特别是偏头痛和丛集性头痛。 本发明还涉及包含式（I）化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP受体的疾病中的用途。