公开(公告)号：US20100168008A1

公开(公告)日：2010-07-01

申请号：US12515492

申请日：2007-11-19

申请人： Muralidhara Padigaru ,  Somesh Sharma ,  Arvind Thakkar ,  Anandharajan Rathina Sabapathy ,  Sapna Hasit Parikh ,  Usha Ghosh

发明人： Muralidhara Padigaru ,  Somesh Sharma ,  Arvind Thakkar ,  Anandharajan Rathina Sabapathy ,  Sapna Hasit Parikh ,  Usha Ghosh

IPC分类号： A61K38/18 ,  A61P29/00 ,  A61P19/02 ,  A61P17/06 ,  C12Q1/68 ,  G01N33/00

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： The present invention relates to nucleotide and protein sequences of epiregulin and epiregulin like proteins and nucleotides and methods employing them as a drug response marker in inflammatory conditions. The invention also provides epiregulin protein for treatment of inflammatory conditions like psoriasis and rheumatoid arthritis alone or in combination with one or more anti-inflammatory compounds.

摘要翻译： 本发明涉及上皮蛋白和外调蛋白样蛋白和核苷酸的核苷酸和蛋白质序列以及在炎症状态下使用它们作为药物反应标记的方法。 本发明还提供了用于治疗单独的银屑病和类风湿性关节炎或与一种或多种抗炎化合物组合的炎性病症的外用蛋白。