公开(公告)号：US20230227428A1

公开(公告)日：2023-07-20

申请号：US18011408

申请日：2021-06-21

Applicant: Anaxis Pharma Pty Ltd

Inventor： Jean-Marc Daniel Garnier ,  Martin Brzozowski ,  John Thomas Feutrill ,  Guillaume Laurent Lessene ,  Christopher Gardner ,  Peter Edward Czabotar ,  Angus Cowan ,  Pooja Sharma ,  Carole Annie Schuster-Klein ,  Christophe Poitevin

IPC: C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D403/12 ,  C07D413/14 ,  C07D231/38 ,  A61P29/00

CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D409/14 ,  C07D403/12 ,  C07D413/14 ,  C07D231/38 ,  A61P29/00

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

公开(公告)号：US20230227429A1

公开(公告)日：2023-07-20

申请号：US18011410

申请日：2021-06-18

Applicant: Anaxis Pharma Pty Ltd

Inventor： Jean-Marc Daniel Garnier ,  Martin Brzozowski ,  John Thomas Feutrill ,  Guillaume Laurent Lessene ,  Christopher Gardner ,  Peter Edward Czabotar ,  Angus Cowan ,  Katherine Davies ,  Pooja Sharma ,  Carole Annie Schuster-Klein ,  Christophe Poitevin

IPC: C07D401/12 ,  C07D403/12 ,  C07D231/38 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D231/38 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

公开(公告)号：US20250059188A1

公开(公告)日：2025-02-20

申请号：US18722104

申请日：2022-12-22

Applicant: Anaxis Pharma Pty Ltd

Inventor： Martin Brzozowski ,  Christophe Poitevin ,  Jean-Marc Daniel Garnier ,  Christopher Gardner ,  Guillaume Laurent Lessene ,  Peter Edward Czabotar ,  Carole Annie Schuster-Klein ,  Katherine Davies ,  Angus Cowan ,  Wilhelmus Johannes Antonius Kersten

IPC: C07D471/04 ,  A61K31/4355 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  C07D487/04 ,  C07D491/08 ,  C07D519/00

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.