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公开(公告)号:US20070276020A1
公开(公告)日:2007-11-29
申请号:US10591096
申请日:2005-03-07
申请人: David Boykin , Chad Stephens , W. Evan Secor , Andrea Crowell , Arvind Kumar
发明人: David Boykin , Chad Stephens , W. Evan Secor , Andrea Crowell , Arvind Kumar
IPC分类号: A61K31/341 , A61K31/4184 , A61P33/02 , C07D307/54 , C07D403/10 , C07D405/14 , C07D409/04
CPC分类号: A61K31/341 , A61K31/4184 , C07D235/20 , C07D413/14
摘要: Dicationic compounds for the treatment of T. vaginalis infections are described. The presently described compounds exhibit in vitro activity against metronidazole-sensitive and -resistant T. vaginalis isolates. Furthermore, the presently described compounds demonstrate IC50 concentrations that were not elevated in the metronidazole resistant isolate, suggesting that their activity is not affected by parasite mechanisms that confer resistance to 5-nitroimidizoles.
摘要翻译: 描述了用于治疗阴道炎感染的阳离子化合物。 目前描述的化合物显示针对甲硝唑敏感和抗性阴道分泌物的体外活性。 此外,目前描述的化合物表现出在甲硝唑抗性分离物中未升高的IC 50浓度,表明它们的活性不受赋予5-硝基亚氨基咪唑抗性的寄生虫机制的影响。