公开(公告)号：US07081513B2

公开(公告)日：2006-07-25

申请号：US10169591

申请日：2001-01-08

申请人： Johannes Antonius Gerardus Van Strijp ,  Cornelis Petrus Maria Van Kessel ,  Andreas Paul Peschel

发明人： Johannes Antonius Gerardus Van Strijp ,  Cornelis Petrus Maria Van Kessel ,  Andreas Paul Peschel

IPC分类号： A61K38/00

CPC分类号： C07K14/31 ,  A61K38/00 ,  Y10S530/825

摘要： The invention relates to nucleic acid molecules encoding (poly)peptides having chemotaxis inhibiting (poly)peptides CHIPS activity, to recombinant vectors harboring such molecules, and the host cells carrying the vectors. The invention further relates to methods for preparing recombinant (poly)peptides having CHIPS activity and to the use of such recombinant (poly)peptides having CHIPS activity for diagnosis, prophylaxis and treatment, such as the treatment of inflammation reactions and HIV. In addition, the invention provides therapeutic and diagnostic compositions comprising as the active ingredient the (poly)peptide having CHIPS activity.

摘要翻译： 本发明涉及编码具有趋化性抑制（多）肽CHIPS活性的多肽的核酸分子，携带这种分子的重组载体和携带载体的宿主细胞。 本发明还涉及制备具有CHIPS活性的重组（多）肽的方法，以及使用具有CHIPS活性的重组（多）肽进行诊断，预防和治疗，例如治疗炎症反应和HIV。 此外，本发明提供包含具有CHIPS活性的（多）肽作为活性成分的治疗和诊断组合物。