公开(公告)号：US06531511B1

公开(公告)日：2003-03-11

申请号：US09890061

申请日：2001-10-16

申请人： Roger John Gillespie ,  Nathaniel Julius Thomas Monck ,  Andrew James Bird ,  Simon Edward Ward

发明人： Roger John Gillespie ,  Nathaniel Julius Thomas Monck ,  Andrew James Bird ,  Simon Edward Ward

IPC分类号： A61K3113

CPC分类号： A61K31/13 ,  A61K31/135 ,  A61K31/381 ,  A61K31/41 ,  A61K31/4245 ,  A61K31/433 ,  C07C211/27 ,  C07C211/29 ,  C07C217/60 ,  C07C2603/74 ,  C07D333/20

摘要： The use of a compound of formula (1), as disclosed in the specification, wherein R1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl and aryl, or pharmaceutically acceptable salts thereof, with the proviso that wherein R1 to R4 and R6 are hydrogen, R5 is not selected from CH2CH2NHSO2CH3, CH2CH2NHSO2CF3 and methyl substituted by SO2NH2, SO3H, PO3H2, CONHOH or a heterocyclic group selected from formulae (a), (b), (c), (d) and (e) in the manufacture of a medicament for use in the treatment of a condition generally associated with abnormalities in glutamatergic transmission.

摘要翻译： 使用如说明书中公开的式（1）化合物，其中R 1，R 2，R 3，R 4，R 5和R 6独立地选自氢，烷基和芳基或其药学上可接受的盐，条件是其中 R 1至R 4和R 6为氢，R 5不选自CH 2 CH 2 NHSO 2 CH 3，CH 2 CH 2 NHSO 2 CF 3和被SO 2 NH 2，SO 3 H，PO 3 H 2，CONHOH或选自式（a），（b），（c），（d）和 （e）制备用于治疗通常与谷氨酸能传递异常有关的病症的药物。

公开(公告)号：US06262106B1

公开(公告)日：2001-07-17

申请号：US09600168

申请日：2000-09-13

申请人： Nathaniel Julius Thomas Monck ,  Roger John Gillespie ,  Andrew James Bird

发明人： Nathaniel Julius Thomas Monck ,  Roger John Gillespie ,  Andrew James Bird

IPC分类号： A61K3138

CPC分类号： C07D333/24 ,  C07C257/16 ,  C07C2603/74

摘要： The compound of the above formula wherein R1-R5 are independently selected from hydrogen, alkyl and aryl and prodrugs thereof; and pharmaceutically acceptable salts thereof; and use of the compounds in therapy, particularly for treatment of a condition generally associated with abnormalities in glutamtergic transmission.

摘要翻译： 上式的化合物其中R 1 -R 5独立地选自氢，烷基和芳基及其前药; 及其药学上可接受的盐; 和化合物在治疗中的用途，特别是用于治疗通常与谷氨酸转运异常相关的病症。