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公开(公告)号:US09428564B2
公开(公告)日:2016-08-30
申请号:US13260862
申请日:2010-04-16
申请人: Patrick Most , Mirko Voelkers , Hugo Katus , Andrew Remppis
发明人: Patrick Most , Mirko Voelkers , Hugo Katus , Andrew Remppis
CPC分类号: C07K14/4728 , A61K38/1709 , A61K45/06 , A61K2300/00
摘要: The present invention relates to a peptide comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptide for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical composition comprising said peptide and a method for treating or preventing disorders associated with muscular malfunction using said peptide or said pharmaceutical composition.
摘要翻译: 本发明涉及一种包含来自S100钙结合蛋白家族的肌肉功能增强氨基酸序列的肽。 此外,本发明提供了用于医疗用途的所述肽,特别是用于治疗或预防与肌肉功能障碍相关的疾病,例如骨骼肌或心肌病。 本发明还提供包含所述肽的药物组合物和使用所述肽或所述药物组合物治疗或预防与肌肉功能障碍相关的疾病的方法。
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公开(公告)号:US09453053B2
公开(公告)日:2016-09-27
申请号:US13880705
申请日:2011-10-20
申请人: Patrick Most , Mirko Voelkers , Hugo Katus , Andrew Remppis
发明人: Patrick Most , Mirko Voelkers , Hugo Katus , Andrew Remppis
CPC分类号: C07K14/001 , A61K38/1738 , C07K14/4728 , C07K2319/10
摘要: The present invention relates to shortened peptides comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptides for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical compositions comprising said peptides and a method for treating or preventing disorders associated with muscular malfunction using said peptides or said pharmaceutical compositions.
摘要翻译: 本发明涉及包含来自S100钙结合蛋白家族的肌肉功能增强氨基酸序列的缩短肽。 此外,本发明提供了所述用于医疗用途的肽,特别是用于治疗或预防与肌肉功能障碍相关的疾病,例如骨骼肌或心肌病。 本发明还提供包含所述肽的药物组合物和使用所述肽或所述药物组合物治疗或预防与肌肉功能障碍相关的疾病的方法。
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公开(公告)号:US20130288971A1
公开(公告)日:2013-10-31
申请号:US13880705
申请日:2011-10-20
申请人: Patrick Most , Mirko Voelkers , Hugo Katus , Andrew Remppis
发明人: Patrick Most , Mirko Voelkers , Hugo Katus , Andrew Remppis
IPC分类号: C07K14/00
CPC分类号: C07K14/001 , A61K38/1738 , C07K14/4728 , C07K2319/10
摘要: The present invention relates to shortened peptides comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptides for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical compositions comprising said peptides and a method for treating or preventing disorders associated with muscular malfunction using said peptides or said pharmaceutical compositions.
摘要翻译: 本发明涉及包含来自S100钙结合蛋白家族的肌肉功能增强氨基酸序列的缩短肽。 此外,本发明提供了所述用于医疗用途的肽,特别是用于治疗或预防与肌肉功能障碍相关的疾病,例如骨骼肌或心肌病。 本发明还提供包含所述肽的药物组合物和使用所述肽或所述药物组合物治疗或预防与肌肉功能障碍相关的疾病的方法。
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公开(公告)号:US20120129758A1
公开(公告)日:2012-05-24
申请号:US13260862
申请日:2010-04-16
申请人: Patrick Most , Mirko Voelkers , Hugo Katus , Andrew Remppis
发明人: Patrick Most , Mirko Voelkers , Hugo Katus , Andrew Remppis
CPC分类号: C07K14/4728 , A61K38/1709 , A61K45/06 , A61K2300/00
摘要: The present invention relates to a peptide comprising a muscle function enhancing amino acid sequence which is derived from the S100 calcium binding protein family. Furthermore, the present invention provides said peptide for medical use, in particular, for treating or preventing disorders associated with muscular malfunction, such as skeletal muscle or cardiac muscle disorders. The present invention also provides a pharmaceutical composition comprising said peptide and a method for treating or preventing disorders associated with muscular malfunction using said peptide or said pharmaceutical composition.
摘要翻译: 本发明涉及一种包含来自S100钙结合蛋白家族的肌肉功能增强氨基酸序列的肽。 此外,本发明提供了用于医疗用途的所述肽,特别是用于治疗或预防与肌肉功能障碍相关的疾病,例如骨骼肌或心肌病。 本发明还提供包含所述肽的药物组合物和使用所述肽或所述药物组合物治疗或预防与肌肉功能障碍相关的疾病的方法。
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公开(公告)号:US07588756B1
公开(公告)日:2009-09-15
申请号:US09958053
申请日:2000-03-20
申请人: Hugo A. Katus , Andrew Remppis , Patrick Most
发明人: Hugo A. Katus , Andrew Remppis , Patrick Most
IPC分类号: A61K48/00
CPC分类号: C07K14/4728 , A61K38/1709 , C12N15/85
摘要: The invention relates to medicaments for treating cardiac power failure. The medicaments contain a therapeutically effective quantity of one or more S100 protein(s) or one or more mutant or fragments of the same, or contain one or more nucleic acid sequence(s) which code(s) for these amino acid sequences and which are optionally integrated in one or more gene transfer vectors.
摘要翻译: 本发明涉及治疗心脏功能衰竭的药物。 药物含有治疗有效量的一种或多种S100蛋白或其一种或多种突变体或片段,或含有编码这些氨基酸序列的一个或多个核酸序列,以及哪些 任选地整合到一个或多个基因转移载体中。
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