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1.
公开(公告)号:US20110257402A1
公开(公告)日:2011-10-20
申请号:US13083636
申请日:2011-04-11
申请人: Philippe Jablonski , Matthias Nettekoven , Angëlique Patiny-Adam , Hasane Ratni , Heinz Stadler
发明人: Philippe Jablonski , Matthias Nettekoven , Angëlique Patiny-Adam , Hasane Ratni , Heinz Stadler
IPC分类号: C07D471/04
CPC分类号: C07D487/04
摘要: The present invention relates to a compound of formula I wherein R1, R2, R3, Ar, and n are as defined herein or to a pharmaceutically active acid addition salt. Compounds of formula I show a high affinity simultaneously to both the NK1 and the NK3 receptors (dual NK1/NK3 receptor antagonists), useful in the treatment of schizophrenia.
摘要翻译: 本发明涉及其中R 1,R 2,R 3,Ar和n如本文所定义或与药学活性的酸加成盐的式I化合物。 式I的化合物对NK1和NK3受体(双重NK1 / NK3受体拮抗剂)同时显示出高亲和力,可用于治疗精神分裂症。