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公开(公告)号：US4364948A
公开(公告)日：1982-12-21
申请号：US306481
申请日：1981-09-28
IPC分类号： A61K31/435 , A61P25/20 , C07D209/48 , C07D317/28 , C07D405/06 , C07D471/04 , A61K31/44
CPC分类号： C07D209/49 , C07C255/00 , C07D317/28 , C07D405/06 , C07D471/04
摘要： Certain pyrazolo[3,4-b]pyridine compounds which are useful for their activity in the central nervous system of warm-blooded animals, of the following formula (I) ##STR1## wherein R.sub.1 is lower alkyl;R.sub.a is hydrogen and R.sub.b is hydroxy or R.sub.a and R.sub.b combine to form a .dbd.O group;R.sub.5 is hydrogen or lower alkyl; andR.sub.6 is lower alkyl,and the pharmaceutically-acceptable salts thereof.
摘要翻译： 可用于其在温血动物的中枢神经系统中的活性的某些吡唑并[3,4-b]吡啶化合物，其具有下式（I）其中R 1为低级烷基; R a是氢，R b是羟基或R a和R b结合形成a = O基团; R5是氢或低级烷基; 和R6是低级烷基，及其药学上可接受的盐。
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2.发明授权
公开(公告)号：US4645838A
公开(公告)日：1987-02-24
申请号：US624530
申请日：1984-06-25
申请人： Thomas M. Bare , Anthony F. Heald
发明人： Thomas M. Bare , Anthony F. Heald
IPC分类号： C07C51/09 , C07C53/21 , C07D207/38 , C07D231/38 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/14 , C07D491/14 , C07D491/147 , C07D491/22
CPC分类号： C07D231/38 , C07C51/09 , C07C53/21 , C07D207/38 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/14 , C07D491/14
摘要： Compounds of the formula (I): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.7 and R.sup.8 are as described herein, D is oxygen, n is 1 or 2 and the physiologically acceptable salts thereof useful in reducing anxiety in an animal such as man. The compounds are potent anxiolytics having reduced side effects compared to known anxiolytics. Also pharmaceutical compositions, intermediates and methods of treatment and synthesis are described.
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公开(公告)号：US4469870A
公开(公告)日：1984-09-04
申请号：US489681
申请日：1983-04-28
申请人： Callixtus E. Ita , Anthony F. Heald , Peter Egli
发明人： Callixtus E. Ita , Anthony F. Heald , Peter Egli
IPC分类号： C07D413/12
CPC分类号： C07D413/12
摘要： Nitrobenzofurazan derivatives having the formula ##STR1## are provided wherein R.sub.1 and R.sub.2 each is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.3 is hydrogen, hydroxy or lower alkyl; R.sub.4 is hydrogen or lower alkyl; m is 2 or 3; and n is 0, 1 or 2; these compounds are useful analytical tools.
摘要翻译： 提供具有式“IMAGE”的硝基苯并呋咱衍生物，其中R 1和R 2各自为氢，低级烷基或苯基 - 低级烷基; R3是氢，羟基或低级烷基; R4是氢或低级烷基; m为2或3; 且n为0,1或2; 这些化合物是有用的分析工具。
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公开(公告)号：US4395556A
公开(公告)日：1983-07-26
申请号：US345883
申请日：1982-02-04
申请人： Callixtus E. Ita , Anthony F. Heald , Peter Egli
发明人： Callixtus E. Ita , Anthony F. Heald , Peter Egli
IPC分类号： C07D413/12 , C07D271/12
CPC分类号： C07D413/12 , Y10S436/80 , Y10S436/826 , Y10T436/13
摘要： Nitrobenzofurazan derivatives having the formula ##STR1## are provided wherein R.sub.1 and R.sub.2 each is hydrogen, lower alkyl or phenyl-lower alkyl; R.sub.3 is hydrogen, hydroxy or lower alkyl; R.sub.4 is hydrogen or lower alkyl; m is 2 or 3; and n is 0, 1 or 2; these compounds are useful analytical tools.
摘要翻译： 提供具有式“IMAGE”的硝基苯并呋喃衍生物，其中R 1和R 2各自为氢，低级烷基或苯基 - 低级烷基; R3是氢，羟基或低级烷基; R4是氢或低级烷基; m为2或3; 且n为0,1或2; 这些化合物是有用的分析工具。
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公开(公告)号：US4511568A
公开(公告)日：1985-04-16
申请号：US485191
申请日：1983-04-15
申请人： Thomas M. Bare , Anthony F. Heald
发明人： Thomas M. Bare , Anthony F. Heald
IPC分类号： C07C51/09 , C07C53/21 , C07D207/38 , C07D231/38 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/14 , C07D491/14 , C07D491/147 , A61K31/44
CPC分类号： C07D231/38 , C07C51/09 , C07C53/21 , C07D207/38 , C07D401/12 , C07D403/12 , C07D471/04 , C07D471/14 , C07D491/14
摘要： Compounds of the formula (I): ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.7 and R.sup.8 are as described herein, D is oxygen or NR.sup.6, n is 1 or 2 and the physiologically acceptable salts thereof useful in reducing anxiety in an animal such as man. The compounds are potent anxiolytics having reduced side effects compared to known anxiolytics. Also pharmaceutical compositions, intermediates and methods of treatment and synthesis are described.
摘要翻译： 式（I）化合物：其中R 1，R 3，R 4，R 7和R 8如本文所述，D是氧或NR 6，n是1或2，并且其生理上可接受的盐可用于减少焦虑 动物如人。 与已知的抗焦虑药相比，这些化合物是有效的抗焦虑药，其副作用降低。 还描述了药物组合物，中间体和治疗和合成方法。
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