专利检索 ap:"Anthony O. P. King" 第 1 页

1.

发明授权
Trialkylsilyl trifluoromethanesulfonate mediated .alpha.-methylenic carbon functionalization of 4-AZA-5.alpha.-androstan-3-one steroids 失效
标题翻译： 4-AZA-5（ALPHA）-ANDROSTAN-3-ONE STEROIDS的三烯丙基磺酸酯介质（ALPHA） - 甲基碳功能化

公开(公告)号：US5091534A

公开(公告)日：1992-02-25

申请号：US572811

申请日：1990-08-27

申请人： Anthony O. P. King , Sandor Karady , Kevin Anderson , Alan W. Douglas , Newton L. Abramson , Richard F. Shuman

发明人： Anthony O. P. King , Sandor Karady , Kevin Anderson , Alan W. Douglas , Newton L. Abramson , Richard F. Shuman

IPC分类号： C07J73/00 , C07J75/00

CPC分类号： C07J73/005

摘要： A novel single-pot trialkylsilyl trifluoromethanesulfonate (R.sub.3 Si--OTf) mediated process produces derivatives of 4-aza 3-keto steroids at the .alpha.-methylenic carbon through electrophilic substitution. These derivatives are useful in the preparation, through elimination of the substituent on the .alpha.-methylene carbon, of .DELTA.-1 olefin 4-aza 3-keto steroids which are potent inhibitors of 5-.alpha. reductase.