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公开(公告)号：US09617546B2
公开(公告)日：2017-04-11
申请号：US14573423
申请日：2014-12-17
申请人： ARCHEMIX LLC
发明人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号： C12N15/11 , C12N15/115 , A61K47/48
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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2.发明申请公开(公告)号：US20150159158A1
公开(公告)日：2015-06-11
申请号：US14573423
申请日：2014-12-17
申请人： ARCHEMIX LLC
发明人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译： 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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公开(公告)号：US20190185858A1
公开(公告)日：2019-06-20
申请号：US16289374
申请日：2019-02-28
申请人： ARCHEMIX LLC
发明人： CLAUDE BENEDICT , DAVID EPSTEIN , CHARLES WILSON , DILARA MCCAULEY , JEFFREY KURZ , MARKUS KURZ , THOMAS GREENE MCCAULEY , JAMES ROTTMAN
IPC分类号： C12N15/115 , A61K47/60
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号：US08946184B2
公开(公告)日：2015-02-03
申请号：US13783633
申请日：2013-03-04
申请人： Archemix LLC
发明人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号： C12N15/11 , A61K47/48 , C12N15/115
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号：US10947544B2
公开(公告)日：2021-03-16
申请号：US16289374
申请日：2019-02-28
申请人： ARCHEMIX LLC
发明人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号： C12N15/115 , A61K47/60
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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6.发明申请公开(公告)号：US20130237589A1
公开(公告)日：2013-09-12
申请号：US13783633
申请日：2013-03-04
申请人： ARCHEMIX LLC
发明人： Claude BENEDICT , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号： A61K47/48
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译： 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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7.发明申请公开(公告)号：US20170145416A1
公开(公告)日：2017-05-25
申请号：US15207028
申请日：2016-07-11
申请人： ARCHEMIX LLC
发明人： David Epstein , Jeffrey C Kurz
IPC分类号： C12N15/115 , C07K16/22 , A61K9/00 , A61K31/702 , A61K39/395
CPC分类号： C12N15/115 , A61K9/0048 , A61K31/702 , A61K39/3955 , A61K47/60 , C07K16/22 , C07K2317/24 , C12N2310/16 , C12N2320/32
摘要： Methods of treating complement-mediated ocular disorders by administering agents that inhibit a subject's complement component in an amount sufficient to treat the ocular disorder wherein, in a selected embodiment, said agent is an anti-complement aptamer that, in a preferred embodiment, is an anti-C5 aptamer.
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8.发明申请Stabilized Aptamers to Platelet Derived Growth Factor and Their Use as Oncology Therapeutics 审中-公开稳定的血小板衍生生长因子及其作为肿瘤学治疗的用途公开(公告)号：US20160053266A1
公开(公告)日：2016-02-25
申请号：US14849180
申请日：2015-09-09
申请人： ARCHEMIX LLC
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , A61K31/4745 , A61K31/7088 , A61K45/06 , A61K47/60 , C12N2310/16 , C12N2310/335 , C12N2310/351 , C12N2310/353 , C12N2320/30 , C12N2320/31
摘要： Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
摘要翻译： 提供材料和方法用于生产和使用适合于能够以极大的亲和力和特异性结合PDGF，PDGF同种型，PDGF受体，VEGF和VEGF受体或其任何组合的肿瘤学治疗剂的适体。 本发明的组合物特别可用于实体瘤治疗，并且可以单独使用或与已知的细胞毒剂组合用于治疗实体瘤。 还公开了具有一个或多个CpG基序嵌入其中或附着于其上的适体。
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公开(公告)号：US20210332361A1
公开(公告)日：2021-10-28
申请号：US17200536
申请日：2021-03-12
申请人： ARCHEMIX LLC
发明人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号： C12N15/115 , A61K47/60
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号：US20180030446A1
公开(公告)日：2018-02-01
申请号：US15448238
申请日：2017-03-02
申请人： ARCHEMIX LLC
发明人： Claude BENEDICT , David EPSTEIN , Charles WILSON , Dilara MCCAULEY , Jeffrey KURZ , Markus KURZ , Thomas Greene MCCAULEY , James ROTTMAN
IPC分类号： C12N15/115 , A61K47/60
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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