公开(公告)号：US20170137824A1

公开(公告)日：2017-05-18

申请号：US15318638

申请日：2015-06-12

申请人： Indranil BANERJEE ,  Ari HELENIUS ,  Patrick Daniel MATTHIAS ,  Yasuyuki MIYAKE ,  Yohei YAMAUCHI

发明人： Indranil BANERJEE ,  Ari HELENIUS ,  Patrick Daniel MATTHIAS ,  Yasuyuki MIYAKE ,  Yohei YAMAUCHI

IPC分类号： C12N15/113 ,  C07K16/40

CPC分类号： C12N15/1137 ,  A61K31/713 ,  C07K16/40 ,  C07K2317/569 ,  C07K2317/76 ,  C12N2310/14 ,  C12Y305/01098

摘要： The present application provides a method for treating an influenza virus infection in a subject characterised in that a therapeutically effective amount of a modulator of the ubiquitin-binding property of HDAC6 is administered to said subject. The present application also provides an antibody binding to HDAC6 and decreasing or blocking its ubiquitin-binding properties for use in treating an influenza virus infection.

公开(公告)号：US20100272706A1

公开(公告)日：2010-10-28

申请号：US12143621

申请日：2008-06-20

申请人： Jason Mercer ,  Urs Greber ,  Stefan Moese ,  Ari Helenius ,  Lucas Pelkmans

发明人： Jason Mercer ,  Urs Greber ,  Stefan Moese ,  Ari Helenius ,  Lucas Pelkmans

IPC分类号： A61K31/553 ,  A61K31/713 ,  A61K39/395 ,  C12Q1/70 ,  A61P31/12

CPC分类号： A61K31/00 ,  A61K31/407

摘要： This invention provides methods for inhibiting or treating infection by viruses, in particular pox viruses by modulating a kinase, in particular by inhibiting a host cell kinase, involved in mediating viral infection. Methods to identify, validate, and classify the cellular proteins required by viruses during infection of host cells in order to select agents which can inhibit viral infection are described herein. Using a systems biology approach the virus/host cell interaction is studied from initial attachment of the incoming virus to the cell surface, to entry, transcription, replication, biosynthesis, and assembly of progeny particles. The method employs a siRNA screening platform and uses gene silencing to map the ‘viral infectome’—a compilation of cellular proteins that the virus needs to establish infection and drive the infectious cycle. Charting the infectome provides information on the viral biology by the identification of host cell proteins involved in viral infection and allows the development of novel anti-viral drugs that prevent the viruses from establishing productive infection in cells.

摘要翻译： 本发明提供了通过调节激酶，特别是通过抑制介导病毒感染的宿主细胞激酶来抑制或治疗病毒，特别是痘病毒感染的方法。 本文描述了在宿主细胞感染期间鉴定，验证和分类病毒所需的细胞蛋白以选择可抑制病毒感染的药剂的方法。 使用系统生物学方法，从入侵病毒的初始附着到细胞表面，进入，转录，复制，生物合成和后代粒子的组装研究病毒/宿主细胞相互作用。 该方法采用siRNA筛选平台，并使用基因沉默来映射“病毒感染物” - 病毒需要建立感染并驱动感染循环的细胞蛋白质的汇编。 通过鉴定涉及病毒感染的宿主细胞蛋白，制定感染物质提供有关病毒生物学的信息，并允许开发新的抗病毒药物，以防止病毒在细胞中产生生产性感染。

公开(公告)号：US4356169A

公开(公告)日：1982-10-26

申请号：US248785

申请日：1981-03-30

申请人： Kai Simons ,  Ari Helenius

发明人： Kai Simons ,  Ari Helenius

IPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/155 ,  A61K39/205 ,  A61K39/295 ,  C07K14/11 ,  C07K14/115 ,  C07K14/145 ,  A61K39/12

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2760/16022 ,  C12N2760/18622 ,  C12N2760/20222

摘要： The invention relates to a method of preparing immunogenically active, lipid and detergent free soluble aggregates of amphiphilic membrane proteins of influenza and parainfluenza viruses and rhabdoviruses.

摘要翻译： 本发明涉及一种制备流感和副流感病毒和弹状病毒的两亲性膜蛋白的免疫原性，脂质和去污剂的可溶性聚集体的方法。