公开(公告)号：US20090036472A1

公开(公告)日：2009-02-05

申请号：US11815251

申请日：2006-02-01

申请人： Venkata P. Palle ,  Ashwani Verma ,  Rakesh Kumar Singh ,  Yogesh Bhaskarrao Waman ,  Arti Walia ,  Abhijit Ray ,  Geeta Sharma

发明人： Venkata P. Palle ,  Ashwani Verma ,  Rakesh Kumar Singh ,  Yogesh Bhaskarrao Waman ,  Arti Walia ,  Abhijit Ray ,  Geeta Sharma

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P29/00 ,  A61P19/02 ,  A61P11/00 ,  A61P9/00 ,  A61P3/00 ,  A61P3/10 ,  A61P1/00

CPC分类号： C07D471/04

摘要： The present invention relates to novel azabicyclo derivatives of Formula (I) as anti-inflammatory agents which are useful for inhibition and prevention of inflammation and associated pathologies including inflammatory and autoimmune diseases such as sepsis, rheumatoid arthritis, inflammatory bowel disease, type-1 diabetes, asthma, chronic obstructive pulmonary disorder, organ transplant rejection and psoriasis.

摘要翻译： 本发明涉及式（I）的新型氮杂双环衍生物作为抗炎剂，其可用于抑制和预防炎症和相关病理学，包括炎性和自身免疫疾病如败血症，类风湿性关节炎，炎性肠病，1型糖尿病 ，哮喘，慢性阻塞性肺病，器官移植排斥和牛皮癣。