公开(公告)号：US08986952B2

公开(公告)日：2015-03-24

申请号：US13879267

申请日：2012-08-10

申请人： Masazumi Kamohara ,  Hirotsugu Tanaka ,  Yukari Koya ,  Jun Takasaki ,  Atsuo Yonezawa ,  Eiji Yoshimi

发明人： Masazumi Kamohara ,  Hirotsugu Tanaka ,  Yukari Koya ,  Jun Takasaki ,  Atsuo Yonezawa ,  Eiji Yoshimi

IPC分类号： C07K16/22 ,  C12N15/13 ,  C12N15/63 ,  C12N15/85 ,  A61K47/48 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K47/60 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/94

摘要： [Task] To provide an anti-human NGF antibody or an antigen-binding fragment thereof that is excellent in safety by reducing the risk of side effects such as effects on a fetus and thrombus formation while maintaining high neutralizing activity, and to provide means for preventing or treating various diseases in which human NGF is involved in the formation of pathological conditions, by using the antibody or the antibody-binding fragment thereof.[Means for Resolution] An anti-human NGF antibody Fab′ fragment comprising a heavy-chain variable region consisting of an amino acid sequence shown by SEQ ID NO:6 and a light-chain variable region consisting of an amino acid sequence shown by SEQ ID NO:4.

摘要翻译： [任务]提供通过降低副作用（如对胎儿的影响和血栓形成同时保持高的中和活性）的安全性优异的抗人NGF抗体或其抗原结合片段，并提供用于 通过使用抗体或其抗体结合片段，预防或治疗人NGF参与病理状况形成的各种疾病。 [解决手段]包含由SEQ ID NO：6所示的氨基酸序列组成的重链可变区的抗人NGF抗体Fab'片段和由SEQ ID NO：6所示的氨基酸序列组成的轻链可变区 编号：4。

公开(公告)号：US20140155582A1

公开(公告)日：2014-06-05

申请号：US13879267

申请日：2012-08-10

申请人： Masazumi Kamohara ,  Hirotsugu Tanaka ,  Yukari Koya ,  Jun Takasaki ,  Atsuo Yonezawa ,  Eiji Yoshimi

发明人： Masazumi Kamohara ,  Hirotsugu Tanaka ,  Yukari Koya ,  Jun Takasaki ,  Atsuo Yonezawa ,  Eiji Yoshimi

IPC分类号： C07K16/22 ,  A61K47/48

CPC分类号： C07K16/22 ,  A61K47/60 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/94

摘要： [Task] To provide an anti-human NGF antibody or an antigen-binding fragment thereof that is excellent in safety by reducing the risk of side effects such as effects on a fetus and thrombus formation while maintaining high neutralizing activity, and to provide means for preventing or treating various diseases in which human NGF is involved in the formation of pathological conditions, by using the antibody or the antibody-binding fragment thereof.[Means for Resolution] An anti-human NGF antibody Fab′ fragment comprising a heavy-chain variable region consisting of an amino acid sequence shown by SEQ ID NO:6 and a light-chain variable region consisting of an amino acid sequence shown by SEQ ID NO:4.

摘要翻译： [任务]提供通过降低副作用（如对胎儿的影响和血栓形成同时保持高的中和活性）的安全性优异的抗人NGF抗体或其抗原结合片段，并提供用于 通过使用抗体或其抗体结合片段，预防或治疗人NGF参与病理状况形成的各种疾病。 [解决手段]包含由SEQ ID NO：6所示的氨基酸序列组成的重链可变区的抗人NGF抗体Fab'片段和由SEQ ID NO：6所示的氨基酸序列组成的轻链可变区 编号：4。