公开(公告)号：US06858414B2

公开(公告)日：2005-02-22

申请号：US10168042

申请日：2000-11-30

申请人： Vilmos Keri ,  Zoltan Czovek ,  Attila Mezo

发明人： Vilmos Keri ,  Zoltan Czovek ,  Attila Mezo

IPC分类号： C07C259/06 ,  C12P13/02 ,  B01D15/08 ,  C07C259/04 ,  C07C309/00 ,  C12P13/00

CPC分类号： C07C259/06

摘要： The present invention provides a purification process whereby deferoxamine B produced by a microorganism and in mixture with other polyhydroxamates produced by the microorganism may be converted into its mesylate salt substantially free of the other polyhydroxamates and substantially free of chloride ion. The process includes adsorption and desorption of the deferoxamine B on an adsorption resin, direct precipitation of the deferoxamine free base out of the eluent from the adsorption resin, contacting of the deferoxamine B free base with methanesulfonic acid and isolation of the deferoxamine B mesylate salt by precipitation. This process minimizes decomposition of deferoxamine B.

摘要翻译： 本发明提供了一种纯化方法，其中由微生物产生的去铁胺B与由微生物产生的其它多羟基羟胺化合物混合可以转化为基本上不含其它多羟基异羟酸酯并基本上不含氯离子的甲磺酸盐。 该方法包括去铁胺B在吸附树脂上的吸附和解吸，从吸附树脂中将脱铁胺游离碱从洗脱液中直接沉淀出，脱铁胺B游离碱与甲磺酸接触，并通过以下步骤分离去铁胺B甲磺酸盐： 沉淀。 该方法使去铁胺B的分解最小化