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1.发明申请NOVEL CROSSLINKED PEI NANOPARTICLE BASED TRANSFECTION AGENTS FOR DELIVERY OF BIOMOLECULES 失效用于交付生物分子的新型交联豌豆纳米脂转移剂公开(公告)号：US20100029750A1
公开(公告)日：2010-02-04
申请号：US12181798
申请日：2008-07-29
Applicant: Kailash Chand GUPTA , Pradeep KUMAR , Archana SWAMI , Atul PATHAK
Inventor： Kailash Chand GUPTA , Pradeep KUMAR , Archana SWAMI , Atul PATHAK
IPC: A61K31/7088 , C08G73/00 , C12N15/12
CPC classification number: A61K31/7088 , A61K9/5146 , A61K48/00 , C08G73/0206 , C12N15/87
Abstract: The present invention relates to a novel crosslinked polyethylenimine (PEI) nanoparticle based nucleic acid transfection agent wherein the crosslinker is having carbon chain in the range of C2 to C8, ranging between 3.27-19.8%, having the size of nanoparticle ranging between 20-600 nm and zeta potential ranging from +5 to 50 mV.
Abstract translation: 本发明涉及基于新型交联聚乙烯亚胺（PEI）纳米颗粒的核酸转染剂，其中交联剂具有在C2至C8范围内的碳链，范围在3.27-19.8％之间，纳米颗粒的尺寸范围在20-600之间 nm和zeta电位范围为+5至50mV。
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2.发明授权Crosslinked PEI nanoparticle transfection agents for delivery of biomolecules with increased efficiency 失效交联的PEI纳米颗粒转染剂，用于递送生物分子，效率提高公开(公告)号：US08513206B2
公开(公告)日：2013-08-20
申请号：US12181798
申请日：2008-07-29
Applicant: Kailash Chand Gupta , Pradeep Kumar , Archana Shami , Atul Pathak
Inventor： Kailash Chand Gupta , Pradeep Kumar , Archana Shami , Atul Pathak
CPC classification number: A61K31/7088 , A61K9/5146 , A61K48/00 , C08G73/0206 , C12N15/87
Abstract: The present invention relates to a novel crosslinked polyethylenimine (PEI) nanoparticle based nucleic acid transfection agent wherein the crosslinker is having carbon chain in the range of C2 to C8, ranging between 3.27-19.8%, having the size of nanoparticle ranging between 20-600 nm and zeta potential ranging from +5 to 50 mV.
Abstract translation: 本发明涉及基于新型交联聚乙烯亚胺（PEI）纳米颗粒的核酸转染剂，其中交联剂具有在C2至C8范围内的碳链，范围在3.27-19.8％之间，纳米颗粒的尺寸范围在20-600之间 nm和zeta电位范围为+5至50mV。
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