公开(公告)号：US20130102796A1

公开(公告)日：2013-04-25

申请号：US13581975

申请日：2011-02-28

申请人： Je-Tae Woo ,  Ayaka Hibino ,  Takayuki Yonezawa ,  Midori Asai ,  Toshiaki Teruya ,  Byung-Yoon Cha ,  Kazuo Nagai

发明人： Je-Tae Woo ,  Ayaka Hibino ,  Takayuki Yonezawa ,  Midori Asai ,  Toshiaki Teruya ,  Byung-Yoon Cha ,  Kazuo Nagai

IPC分类号： A61K31/353

CPC分类号： A61K31/353 ,  A61K31/352 ,  C07D311/16 ,  C07D311/18 ,  Y02A50/409

摘要： Agents or pharmaceutical compositions for promoting osteoblast differentiation include purified auraptene or coumarin analogs thereof represented by the following formula 1: wherein R1 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, or a carboxyethyl; R2 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, a carboxyethyl or a coumarinyl; R3 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl or a carboxyethyl; and R4 represents a hydrogen, a C1-C15 liner or branched alkyl, an alkenyl, an alkadienyl or an alkatrienyl.

摘要翻译： 用于促进成骨细胞分化的试剂或药物组合物包括由下式1表示的纯化的紫罗烯或其香豆素类似物：其中R 1表示氢，羟基，甲氧基，甲基，乙基，丙基，羧基，羧甲基或 羧乙基; R 2表示氢，羟基，甲氧基，甲基，乙基，丙基，羧基，羧甲基，羧基乙基或香豆素基; R3表示氢，羟基，甲氧基，甲基，乙基，丙基，羧基，羧甲基或羧基乙基; 并且R 4表示氢，C 1 -C 15内衬或支链烷基，烯基，链二烯基或链亚三烯基。

公开(公告)号：US08729279B2

公开(公告)日：2014-05-20

申请号：US13581975

申请日：2011-02-28

申请人： Je-Tae Woo ,  Ayaka Hibino ,  Takayuki Yonezawa ,  Midori Asai ,  Toshiaki Teruya ,  Byung-Yoon Cha ,  Kazuo Nagai

发明人： Je-Tae Woo ,  Ayaka Hibino ,  Takayuki Yonezawa ,  Midori Asai ,  Toshiaki Teruya ,  Byung-Yoon Cha ,  Kazuo Nagai

IPC分类号： C07D311/00 ,  C07D311/02

CPC分类号： A61K31/353 ,  A61K31/352 ,  C07D311/16 ,  C07D311/18 ,  Y02A50/409

摘要： Agents or pharmaceutical compositions for promoting osteoblast differentiation include purified auraptene or coumarin analogs thereof represented by the following formula 1: wherein R1 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, or a carboxyethyl; R2 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl, a carboxyethyl or a coumarinyl; R3 represents a hydrogen, a hydroxy, a methoxy, a methyl, an ethyl, a propyl, a carboxyl, a carboxymethyl or a carboxyethyl; and R4 represents a hydrogen, a C1-C15 liner or branched alkyl, an alkenyl, an alkadienyl or an alkatrienyl.

摘要翻译： 用于促进成骨细胞分化的试剂或药物组合物包括由下式1表示的纯化的紫罗烯或其香豆素类似物：其中R 1表示氢，羟基，甲氧基，甲基，乙基，丙基，羧基，羧甲基或 羧乙基; R 2表示氢，羟基，甲氧基，甲基，乙基，丙基，羧基，羧甲基，羧基乙基或香豆素基; R3表示氢，羟基，甲氧基，甲基，乙基，丙基，羧基，羧甲基或羧基乙基; 并且R 4表示氢，C 1 -C 15内衬或支链烷基，烯基，链二烯基或链亚三烯基。