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1.发明申请Peptide Minotopes of Mycobacterial Mannosylated Lipoglycans and Uses Thereof 有权分枝杆菌Mannosylated Lipoglycans的肽微粒及其用途公开(公告)号：US20070292447A1
公开(公告)日：2007-12-20
申请号：US10589866
申请日：2005-02-17
CPC分类号： G01N33/5695 , G01N33/6854 , Y10S530/806 , Y10S530/807
摘要： The present invention relates to the identification of antigenic and immunogenic peptide-based mimicry of mannose-containing cell-wall compounds characterizing mycobacterial infectious agents, such as Mycobacterium tuberculosis. Amino acid molecules which are mimotopes of mannosylated lipoglycans, such as lipoarabinomannan (ManLAM), including at least one of the following characteristics: (a) being capable of binding to ManLAM binding antibodies; (b) being capable of eliciting production of ManLAM binding antibodies, are provided. Also diagnostic methods for diagnosing mycobacterial infections and methods of vaccinating subjects against such infections. The diagnostic and vaccination methods employ the provided amino acid molecules. Accordingly, a diagnostic kit and a vaccine for executing the aforementioned methods are provided.
摘要翻译： 本发明涉及鉴定表达分枝杆菌感染因子如结核分枝杆菌的含有甘露糖的细胞壁化合物的抗原性和免疫原性的基于肽的模拟物。 作为甘露糖基化脂聚糖的模拟表位的氨基酸分子，例如脂褐素甘露聚糖（ManLAM），其包括以下特征中的至少一个：（a）能够结合ManLAM结合抗体; （b）能引起ManLAM结合抗体的产生。 用于诊断分枝杆菌感染的诊断方法以及接种针对这种感染的受试者的方法。 诊断和接种方法使用提供的氨基酸分子。 因此，提供了用于执行上述方法的诊断试剂盒和疫苗。
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2.发明授权Use of mycobacterial mannosylated lipoglycans peptide mimotopes for treating inflammation 有权使用分枝杆菌甘露糖基脂聚糖肽模拟表位来治疗炎症公开(公告)号：US08147837B2
公开(公告)日：2012-04-03
申请号：US11630115
申请日：2005-06-23
申请人： Herve Bercovier , Ayelet Barenholz
发明人： Herve Bercovier , Ayelet Barenholz
IPC分类号： A61K39/00
摘要： The present invention is based on the discovery that biological peptide-based mimotopes of mannose-containing cell-wall compounds of Mycobacterium tuberculosis, specifically, ManLAM, have an anti-inflammatory effect and immunoregulator effect in animal models of inflammation. Such models include animal models of allergic peritonitis, allergic asthma and septic shock model (mice injected with LPS) and in Crohn's disease model (TNBS-induced colitis). Thus, the present invention concerns the use a molecule, particularly, an amino acid based molecule for the production of a pharmaceutical composition for the treatment of an inflammatory condition, the amino acid comprising one or more peptides characterized in that it can bind to ManLAM binding antibodies; and/or it can elicit an immune response in a subject inoculated therewith, giving rise to production of ManLAM-binding antibodies. The invention also provides pharmaceutical compositions for treating inflammatory conditions and comprising the amino acid-based molecule, as well as to methods of treatment of such conditions by administering to a subject an amount of the amino-acid based molecules.
摘要翻译： 本发明基于以下发现：结核分枝杆菌的具有甘露糖的细胞壁化合物，特别是ManLAM的基于生物肽的模拟表位在炎症的动物模型中具有抗炎作用和免疫调节剂作用。 这些模型包括过敏性腹膜炎，过敏性哮喘和败血性休克模型（注射LPS的小鼠）和克罗恩病模型（TNBS诱导的结肠炎）的动物模型。 因此，本发明涉及使用分子，特别是用于制备用于治疗炎性病症的药物组合物的基于氨基酸的分子，所述氨基酸包含一种或多种肽，其特征在于其可以结合ManLAM结合 抗体; 和/或可以在接种的受试者中引发免疫应答，从而产生ManLAM结合抗体。 本发明还提供了用于治疗炎性病症并包含基于氨基酸的分子的药物组合物，以及通过向受试者施用一定量的氨基酸基分子来治疗这些病症的方法。
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3.发明授权Peptide mimotopes of mycobacterial mannosylated lipoglycans and uses thereof 有权分枝杆菌甘露糖基化脂聚糖的肽模拟表位及其用途公开(公告)号：US07892557B2
公开(公告)日：2011-02-22
申请号：US10589866
申请日：2005-02-17
CPC分类号： G01N33/5695 , G01N33/6854 , Y10S530/806 , Y10S530/807
摘要： The present invention relates to the identification of antigenic and immunogenic peptide-based mimicry of mannose-containing cell-wall compounds characterizing mycobacterial infectious agents, such as Mycobacterium tuberculosis. Amino acid molecules which are mimotopes of mannosylated lipoglycans, such as lipoarabinomannan (ManLAM), including at least one of the following characteristics: (a) being capable of binding to ManLAM binding antibodies; (b) being capable of eliciting production of ManLAM binding antibodies, are provided.Also diagnostic methods for diagnosing mycobacterial infections and methods of vaccinating subjects against such infections. The diagnostic and vaccination methods employ the provided amino acid molecules.Accordingly, a diagnostic kit and a vaccine for executing the aforementioned methods are provided.
摘要翻译： 本发明涉及鉴定表达分枝杆菌感染因子如结核分枝杆菌的含有甘露糖的细胞壁化合物的抗原性和免疫原性的基于肽的模拟物。 作为甘露糖基化脂聚糖的模拟表位的氨基酸分子，例如脂褐素甘露聚糖（ManLAM），其包括以下特征中的至少一个：（a）能够结合ManLAM结合抗体; （b）能引起ManLAM结合抗体的产生。 用于诊断分枝杆菌感染的诊断方法以及接种针对这种感染的受试者的方法。 诊断和接种方法使用提供的氨基酸分子。 因此，提供了用于执行上述方法的诊断试剂盒和疫苗。
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4.发明申请Use of Mycobacterial Mannosylated Lipoglycans Peptide Mimotopes For Treating Inflammation 有权使用分枝杆菌Mannosylated Lipoglycans肽模拟表位用于治疗炎症公开(公告)号：US20080318868A1
公开(公告)日：2008-12-25
申请号：US11630115
申请日：2005-06-23
申请人： Herve Bercovier , Ayelet Barenholz
发明人： Herve Bercovier , Ayelet Barenholz
摘要： The present invention is based on the discovery that biological peptide-based mimotopes of mannose-containing cell-wall compounds of Mycobacterium tuberculosis, specifically, ManLAM, have an anti-inflammatory effect and immunoregulator effect in animal models of inflammation. Such models include animal models of allergic peritonitis, allergic asthma and septic shock model (mice injected with LPS) and in Crohn's disease model (TNBS-induced colitis). Thus, the present invention concerns the use a molecule, particularly, an amino acid based molecule for the production of a pharmaceutical composition for the treatment of an inflammatory condition, the amino acid comprising one or more peptides characterized in that it can bind to ManLAM binding antibodies; and/or it can elicit an immune response in a subject inoculated therewith, giving rise to production of ManLAM-binding antibodies. The invention also provides pharmaceutical compositions for treating inflammatory conditions and comprising the amino acid-based molecule, as well as to methods of treatment of such conditions by administering to a subject an amount of the amino-acid based molecules.
摘要翻译： 本发明基于以下发现：结核分枝杆菌的具有甘露糖的细胞壁化合物，特别是ManLAM的基于生物肽的模拟表位在炎症的动物模型中具有抗炎作用和免疫调节剂作用。 这些模型包括过敏性腹膜炎，过敏性哮喘和败血性休克模型（注射LPS的小鼠）和克罗恩病模型（TNBS诱导的结肠炎）的动物模型。 因此，本发明涉及使用分子，特别是用于制备用于治疗炎性病症的药物组合物的基于氨基酸的分子，所述氨基酸包含一种或多种肽，其特征在于其可以结合ManLAM结合 抗体; 和/或可以在接种的受试者中引发免疫应答，从而产生ManLAM结合抗体。 本发明还提供了用于治疗炎性病症并包含基于氨基酸的分子的药物组合物，以及通过向受试者施用一定量的氨基酸基分子来治疗这些病症的方法。
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