公开(公告)号：US09974763B2

公开(公告)日：2018-05-22

申请号：US14894621

申请日：2014-05-28

Applicant: B & A THERAPEUTICS ,  CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE D'AIX-MARSEILLE ,  UNIVERSITE DE NANTES

Inventor： Yehezkel Ben-Ari ,  Nathalie Dehorter ,  Philippe Damier ,  Constance Hammond

IPC: A61K31/196 ,  A61K45/06 ,  C12N15/113 ,  A61K31/192

CPC classification number: A61K31/196 ,  A61K31/192 ,  A61K45/06 ,  C12N15/1138 ,  A61K2300/00

Abstract: A composition for treating Neurodegenerative Diseases with Parkinsonian Syndromes in a subject in need thereof, wherein the composition includes an effective amount of a modulator of a chloride transporter.

公开(公告)号：US20160312229A1

公开(公告)日：2016-10-27

申请号：US15104895

申请日：2014-12-18

Applicant: Fondazione Istituto Italiano di Tecnologia ,  B & A Therapeutics

Inventor： Laura Cancedda ,  Yehezkel Ben-Ari ,  Andrea Constestabile

IPC: C12N15/113 ,  A61K31/196

CPC classification number: C12N15/1138 ,  A61K31/196 ,  A61K31/40 ,  A61K31/427 ,  A61K31/517 ,  A61K31/549 ,  A61K31/635 ,  A61K31/64 ,  A61K31/7105 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/531 ,  C12N2320/32 ,  A61K2300/00

Abstract: Modulators of intracellular chloride concentration for treating down syndrome The present invention relates to a modulator of a chloride transporter for use in the treatment of Down syndrome.

Abstract translation: 用于治疗唐氏综合征的细胞内氯化物浓度的调节剂本发明涉及用于治疗唐氏综合征的氯转运体的调节剂。

公开(公告)号：US20160106693A1

公开(公告)日：2016-04-21

申请号：US14894621

申请日：2014-05-28

Applicant: B & A THERAPEUTICS ,  CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITÉ D'AIX-MARSEILLE ,  UNIVERSITÉ DE NANTES

Inventor： Yehezkel BEN-ARI ,  Nathalie DEHORTER ,  Philippe DAMIER ,  Constance HAMMOND

IPC: A61K31/196 ,  A61K45/06

CPC classification number: A61K31/196 ,  A61K31/192 ,  A61K45/06 ,  C12N15/1138 ,  A61K2300/00

Abstract: A composition for treating Neurodegenerative Diseases with Parkinsonian Syndromes in a subject in need thereof, wherein the composition includes an effective amount of a modulator of a chloride transporter.

Abstract translation: 用于在有需要的受试者中用于治疗患有帕金森综合征的神经变性疾病的组合物，其中所述组合物包含有效量的氯化物转运蛋白的调节剂。

公开(公告)号：US09822368B2

公开(公告)日：2017-11-21

申请号：US15104895

申请日：2014-12-18

Applicant: Fondazione Istituto Italiano di Tecnologia ,  B & A Therapeutics

Inventor： Laura Cancedda ,  Yehezkel Ben-Ari ,  Andrea Constestabile

IPC: A61K31/64 ,  C12N15/113 ,  A61K31/196 ,  A61K31/40 ,  A61K31/427 ,  A61K31/517 ,  A61K31/549 ,  A61K31/635 ,  A61K31/7105

CPC classification number: C12N15/1138 ,  A61K31/196 ,  A61K31/40 ,  A61K31/427 ,  A61K31/517 ,  A61K31/549 ,  A61K31/635 ,  A61K31/64 ,  A61K31/7105 ,  C12N2310/11 ,  C12N2310/12 ,  C12N2310/122 ,  C12N2310/14 ,  C12N2310/16 ,  C12N2310/531 ,  C12N2320/32 ,  A61K2300/00

Abstract: Modulators of intracellular chloride concentration for treating down syndrome The present invention relates to a modulator of a chloride transporter for use in the treatment of Down syndrome.