摘要:
A SERIES OF TRIFLUOROMETHYL SUBSTITUTED-2,6-DIPHENYL-4PYRIDYLCARBINOLAMINES IS HEREIN DISCLOSED WHICH HAS VALUE IN TREATMENT OF PALSMODIAL INFECTIONS. THE COMPOUNDS HAVE SUBSTITUTED PHENYL GROUPS AT POSITIONS 2- AND 6- ON THE PYRIDINE MOIETY, WITH THE ELECTRONEGATIVE SUBSTITUENTS (THE SAME, OR DIFFERENT) PRESENT ON THE PHENYL NUCLEI AT LEAST ONE OF WHICH IS TRIFLUOROMETHYL. THE SYNTHESES OF SUCH SERIES IS DESCRIBED, TOGETHER WITH A METHOD FOR SEPRATION OF RACEMATES OF A REPRESENTATIVE 4-PYRIDYLCARBINOLAMINE TYPE.
摘要:
A SERIES OF TRIFLUOROMETHYL SUBSTITUTED-2,6-DIPHENYL-4PYRIDYLCARBINOLAMINES IS HEREIN DISCLOSED WHICH HAS VALUE IN TREATMENT OF PLASMODIAL INFECTIONS. THE COMPOUNDS HAVE SUBSTITUTED PHENYL GROUPS AT POSITIONS 2- AND 6- ON THE PYRIDINE MOIETY, WITH THE ELECTRONEGATIVE SUBSTITUENTS (THE SAME, OR DIFFERENT) PRESENT ON THE PHENYL NUCLEI AT LEAST ONE OF WHICH IS TRIFLUOROMETHYL. THE SYNTHESES OF SUCH SERIES IS DESCRIBED, TOGETHER WITH A METHOD FOR SEPARATION OF RACEMATES OF A REPRESENTATIVE 4-PYRIYLCAR BINOLAMINE TYPE.