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1.发明授权Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof 失效厄洛替尼或其药学上可接受的盐的制备方法公开(公告)号：US08440823B2
公开(公告)日：2013-05-14
申请号：US13258961
申请日：2010-03-26
申请人： Balaguru Murugesan , Anandam Vempali , Swargam Sathyanarayana , Rajesh Kumar Thaper , Mohan Prasad
发明人： Balaguru Murugesan , Anandam Vempali , Swargam Sathyanarayana , Rajesh Kumar Thaper , Mohan Prasad
IPC分类号： C07D401/00
CPC分类号： C07D239/94
摘要： The present invention relates to a process for preparation of erlotinib of Formula I or its pharmaceutically acceptable salt thereof. The present invention also relates to process for the preparation of erlotinib trifluoroacetate. The present invention also relates to a nove-ICrystalline form of erlotinib trifluoroacetate designated as Form E and process for its preparation. The present invention further relates to process for the preparation of erlotinib hydrochloride from erlotinib trifluoroacetate.
摘要翻译： 本发明涉及制备式I的厄洛替尼或其药学上可接受的盐的方法。 本发明还涉及制备三氟醋酸埃洛替尼的方法。 本发明还涉及一种名为E型的埃洛替尼三氟乙酸盐的结晶形式及其制备方法。 本发明还涉及从埃罗替尼三氟醋酸盐制备盐酸埃罗替尼的方法。
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2.发明申请PROCESSES FOR THE PREPARATION OF ERLOTINIB HYDROCHLORIDE FORM A AND ERLOTINIB HYDROCHLORIDE FORM B 审中-公开ERLOTINIB氢氯酸盐形式A和ERLOTINIB氢氯化物形式B的制备方法公开(公告)号：US20120302749A1
公开(公告)日：2012-11-29
申请号：US13509031
申请日：2010-11-12
申请人： Balaguru Murugesan , Anandam Vempali , Swargam Sathyanarayana , Rajesh Kumar Thaper , Mohan Prasad
发明人： Balaguru Murugesan , Anandam Vempali , Swargam Sathyanarayana , Rajesh Kumar Thaper , Mohan Prasad
IPC分类号： C07D239/94
CPC分类号： C07D239/94
摘要： The present invention relates to processes for the preparation of erlotinib hydrochloride Form A and erlotinib hydrochloride Form B. (I).
摘要翻译： 本发明涉及制备盐酸埃罗替尼形式A和盐酸埃洛替尼B型（I）的方法。
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公开(公告)号：US20120184746A1
公开(公告)日：2012-07-19
申请号：US13393699
申请日：2010-09-03
申请人： Munish Kapoor , Saridi Madhava Dileep Kumar , Balaguru Murugesan , Swargam Sathyanarayana , Rajesh Kumar Thaper , Mohan Prasad
发明人： Munish Kapoor , Saridi Madhava Dileep Kumar , Balaguru Murugesan , Swargam Sathyanarayana , Rajesh Kumar Thaper , Mohan Prasad
IPC分类号： C07D401/04
CPC分类号： C07D401/04
摘要： The present invention relates to a process for the preparation of lenalidomide, wherein the process comprises: reducing 3-(4-nitro-loxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione to obtain lenalidomide.
摘要翻译： 本发明涉及一种制备来那度塞的方法，其中该方法包括：将3-（4-硝基 - 氯-1,3-二氢-2H-异吲哚-2-基）哌啶-2,6-二酮还原成 获得来那度胺。
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公开(公告)号：US20120101281A1
公开(公告)日：2012-04-26
申请号：US13258661
申请日：2010-03-26
IPC分类号： C07D221/16
CPC分类号： C07D401/04
摘要： The present invention provides a process for the preparation of desloratadine comprising contacting loratadine with a mixture of a weak inorganic base and sodium or potassium hydroxide in a ratio, ranging from 0.01 to 0.15 equivalents of sodium or potassium hydroxide per equivalent of weak inorganic base, in one or more suitable solvents) followed by isolation.
摘要翻译： 本发明提供了一种制备去氯雷他定的方法，该方法包括使弱氯酸钠与弱无机碱和氢氧化钠或氢氧化钾的混合物的比例为0.01至0.15当量的氢氧化钠或氢氧化钾/当量的无机碱， 一种或多种合适的溶剂），然后分离。
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5.发明申请PROCESS FOR THE PREPARATION OF ERLOTINIB OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF 失效制备ERLOTINIB或其药学上可接受的药物的方法公开(公告)号：US20120101272A1
公开(公告)日：2012-04-26
申请号：US13258961
申请日：2010-03-26
申请人： Balaguru Murugesan , Anandam Vempali , Swargam Sathyanarayana , Rajesh Kumar Thaper , Mohan Prasad
发明人： Balaguru Murugesan , Anandam Vempali , Swargam Sathyanarayana , Rajesh Kumar Thaper , Mohan Prasad
IPC分类号： C07D237/34
CPC分类号： C07D239/94
摘要： The present invention relates to a process for preparation of erlotinib of Formula I or its pharmaceutically acceptable salt thereof. The present invention also relates to process for the preparation of erlotinib trifluoroacetate. The present invention also relates to a nove-ICrystalline form of erlotinib trifluoroacetate designated as Form E and process for its preparation. The present invention further relates to process for the preparation of erlotinib hydrochloride from erlotinib trifluoroacetate.
摘要翻译： 本发明涉及制备式I的厄洛替尼或其药学上可接受的盐的方法。 本发明还涉及制备三氟醋酸埃洛替尼的方法。 本发明还涉及一种名为E型的埃洛替尼三氟乙酸盐的结晶形式及其制备方法。 本发明还涉及从埃罗替尼三氟醋酸盐制备盐酸埃罗替尼的方法。
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