公开(公告)号：US4960931A

公开(公告)日：1990-10-02

申请号：US417995

申请日：1989-10-06

申请人： Donald E. Butler ,  Barbara J. Greenman

发明人： Donald E. Butler ,  Barbara J. Greenman

IPC分类号： C07C229/28

CPC分类号： C07C229/28 ,  C07C2101/14

摘要： A novel crystalline form of gabapentin and a novel processes for the small and large scale preparations of the anticonvulsant compound in a highly pure state is disclosed. This novel hydrate is produced by a cost effective process which provides an additional purification stage.

摘要翻译： 公开了一种新型的加巴喷丁结晶形式及其在高纯度状态下抗惊厥化合物的小规模制备的新方法。 这种新型水合物是通过成本有效的方法产生的，其提供额外的纯化阶段。

公开(公告)号：US4894476A

公开(公告)日：1990-01-16

申请号：US188819

申请日：1988-05-02

申请人： Donald E. Butler ,  Barbara J. Greenman

发明人： Donald E. Butler ,  Barbara J. Greenman

IPC分类号： A61K31/195 ,  A61P25/00 ,  A61P25/08 ,  C07C227/16 ,  C07C227/40 ,  C07C229/28

CPC分类号： C07C229/28 ,  C07C2101/14

摘要： A novel crystalline form of gabapentin and a novel processes for the small and large scale preparations of the anticonvulsant compound in a highly pure state is disclosed. This novel hydrate is produced by a cost effective process which provides an additional purification stage.