公开(公告)号：US07795591B2

公开(公告)日：2010-09-14

申请号：US12218575

申请日：2008-07-16

申请人： Benjamin L. Welch

发明人： Benjamin L. Welch

IPC分类号： G01T1/166

CPC分类号： A61B6/12 ,  A61B6/037

摘要： A combination rigid grid positioning system, stereotactic gamma imager and an obturator for real-time localization of a region of interest during the performance of a surgical procedure including: a) a rigid grid positioning system including a mechanism for the acquisition of images useful in calculating the spatial location of a region of interest in a mass under study; and b) an obturator inserted through the rigid grid positioning system made up of: i) first and second generally parallel capillary tubes for the introduction thereto and the removal therefrom of a radioactive fluid interconnected at a point of connection; and ii) a reservoir for the radioactive fluid at the point of connection; wherein the reservoir is inserted into the mass containing a region of interest and the radioactive fluid provides a marker for the region of interest during subsequent imaging and thereby specific localization of the region of interest during subsequent procedures.

摘要翻译： 一种组合刚性网格定位系统，立体定向伽马成像器和用于在外科手术过程中实时定位感兴趣区域的闭孔器，包括：a）刚性网格定位系统，其包括用于获取用于计算的图像的机构 正在研究的群体中感兴趣区域的空间位置; b）通过刚性网格定位系统插入的闭塞器，其由以下部件组成：i）第一和第二大致平行的毛细管，用于引入到其中并从其上移除在连接点处互连的放射性流体; 和ii）在连接点处的放射性流体的储存器; 其中所述储存器插入到包含感兴趣区域的物质中，并且放射性流体在随后的成像期间为感兴趣区域提供标记，从而在随后的程序期间特定地定位感兴趣区域。

公开(公告)号：US20100012848A1

公开(公告)日：2010-01-21

申请号：US12218601

申请日：2008-07-16

申请人： Benjamin L. Welch

发明人： Benjamin L. Welch

IPC分类号： G01T1/166 ,  A61B6/00

CPC分类号： A61B6/4258 ,  A61B90/11 ,  A61B90/37 ,  A61B2017/3411 ,  A61B2090/371 ,  A61B2090/392

摘要： A combination rigid imager and obturator for real-time localization of a region of interest during the performance of a surgical procedure that includes: a) a rigid imaging grid preferably made up of an array of gamma radiation position sensitive photomultipliers; and b) an obturator inserted through the rigid imaging grid into a mass containing a region of interest and including: 1) an outer tube having a first closed end and a distal open end; and 2) an inner tube having an inserted end that includes a radioactive tracer and a remote end inserted into the distal open end; wherein the first closed end is inserted into the mass containing a region of interest and the radioactive source provides a marker for the region of interest during the performance of a surgical procedure.

摘要翻译： 用于在外科手术过程中实时定位感兴趣区域的组合刚性成像器和闭孔器，其包括：a）优选由伽马射线位置敏感光电倍增管阵列组成的刚性成像网格; 以及b）通过所述刚性成像网格插入包含感兴趣区域的质量体中的填塞物，并且包括：1）具有第一封闭端和远端开口端的外管; 和2）具有插入端的内管，其包括放射性示踪器和插入所述远端开口端的远端; 其中所述第一封闭端插入含有感兴趣区域的质量块中，并且所述放射源在执行外科手术期间为所述感兴趣区域提供标记。

公开(公告)号：USRE43499E1

公开(公告)日：2012-07-03

申请号：US12913372

申请日：2010-10-27

申请人： Douglas Arthur Kieper ,  Stanislaw Majewski ,  Benjamin L. Welch

发明人： Douglas Arthur Kieper ,  Stanislaw Majewski ,  Benjamin L. Welch

IPC分类号： G06K9/00 ,  A61B6/04

CPC分类号： A61B6/4258 ,  A61B6/502 ,  A61B6/583 ,  G01T1/1642 ,  G01T1/1644

摘要： An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

摘要翻译： 一种用于增强经历双头闪烁物理检查的乳房的背景和病变区域之间的对比度的改进方法，包括：1）从一对小的FOV或迷你伽马照相机获取一对数字图像，以从相对侧压缩检查的乳房; 2）反转一对图像中的一个以对准或共同对准另一个图像，以获得共同注册的像素值; 3）通过将两个获取的图像和共同注册的图像中的每一个的像素值除以相应检测器的整个乳房区域中的每个像素的平均计数来逐像素地归一化该对图像; 以及4）将每个像素中的计数数乘以步骤3中获得的值，以产生归一化增强二维对比图。 这种增强（增强的对比度）对比图增强了背景下活动的局部增加（摄取）的可见性，因此改善了病变检测灵敏度，特别是小病变的敏感性。

公开(公告)号：US20100012847A1

公开(公告)日：2010-01-21

申请号：US12218575

申请日：2008-07-16

申请人： Benjamin L. Welch

发明人： Benjamin L. Welch

IPC分类号： G01T1/166 ,  A61B6/00

CPC分类号： A61B6/12 ,  A61B6/037

摘要： A combination rigid grid positioning system, stereotactic gamma imager and an obturator for real-time localization of a region of interest during the performance of a surgical procedure including: a) a rigid grid positioning system including a mechanism for the acquisition of images useful in calculating the spatial location of a region of interest in a mass under study; and b) an obturator inserted through the rigid grid positioning system made up of: i) first and second generally parallel capillary tubes for the introduction thereto and the removal therefrom of a radioactive fluid interconnected at a point of connection; and ii) a reservoir for the radioactive fluid at the point of connection; wherein the reservoir is inserted into the mass containing a region of interest and the radioactive fluid provides a marker for the region of interest during subsequent imaging and thereby specific localization of the region of interest during subsequent procedures.

公开(公告)号：US07444009B1

公开(公告)日：2008-10-28

申请号：US10961552

申请日：2004-10-08

申请人： Douglas Arthur Kieper ,  Stanislaw Majewski ,  Benjamin L. Welch

发明人： Douglas Arthur Kieper ,  Stanislaw Majewski ,  Benjamin L. Welch

IPC分类号： G06K9/00 ,  A61B6/04

CPC分类号： A61B6/4258 ,  A61B6/502 ,  A61B6/583 ,  G01T1/1642 ,  G01T1/1644

摘要： An improved method for enhancing the contrast between background and lesion areas of a breast undergoing dual-head scintimammographic examination comprising: 1) acquiring a pair of digital images from a pair of small FOV or mini gamma cameras compressing the breast under examination from opposing sides; 2) inverting one of the pair of images to align or co-register with the other of the images to obtain co-registered pixel values; 3) normalizing the pair of images pixel-by-pixel by dividing pixel values from each of the two acquired images and the co-registered image by the average count per pixel in the entire breast area of the corresponding detector; and 4) multiplying the number of counts in each pixel by the value obtained in step 3 to produce a normalization enhanced two dimensional contrast map. This enhanced (increased contrast) contrast map enhances the visibility of minor local increases (uptakes) of activity over the background and therefore improves lesion detection sensitivity, especially of small lesions.

摘要翻译： 一种用于增强经历双头闪烁物理检查的乳房的背景和病变区域之间的对比度的改进方法，包括：1）从一对小的FOV或迷你伽马照相机获取一对数字图像，以从相对侧压缩检查的乳房; 2）反转一对图像中的一个以对准或共同对准另一个图像，以获得共同注册的像素值; 3）通过将两个获取的图像和共同注册的图像中的每一个的像素值除以相应检测器的整个乳房区域中的每个像素的平均计数来逐像素地归一化该对图像; 以及4）将每个像素中的计数数乘以步骤3中获得的值，以产生归一化增强二维对比图。 这种增强（增强的对比度）对比图增强了背景下活动的局部增加（摄取）的可见性，因此改善了病变检测灵敏度，特别是小病变的敏感性。