公开(公告)号：US20150158934A1

公开(公告)日：2015-06-11

申请号：US14343430

申请日：2012-09-10

申请人： Laura Ellen Fleet McCoy ,  Lucy Rutten ,  Nika Mindy Strokappe ,  Cornelis Theodorus Verrips ,  Benjamin Lucian John Webb ,  Robert Anthony Weiss

发明人： Laura Ellen Fleet McCoy ,  Lucy Rutten ,  Nika Mindy Strokappe ,  Cornelis Theodorus Verrips ,  Benjamin Lucian John Webb ,  Robert Anthony Weiss

IPC分类号： C07K16/10

CPC分类号： C07K16/1063 ,  C07K16/1045 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/76

摘要： The invention relates to a novel class of broadly neutralizing anti-HIV antibodies, more specifically to broadly neutralizing heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies for diagnostic and therapeutic and/or prophylactic treatment of individuals that are infected with HIV, or are at risk of becoming infected.

摘要翻译： 本发明涉及一类广泛中和的抗HIV抗体，更具体地涉及广泛中和重链可变结构域抗体（VHH）及其变体和修饰。 本发明还涉及用于产生这些抗体的方法以及用于诊断和治疗和/或预防性地治疗感染HIV的个体或有被感染风险的抗体的用途。