公开(公告)号：US4997824A

公开(公告)日：1991-03-05

申请号：US76459

申请日：1987-07-22

申请人： Mordecai Popovtzer ,  Ben Z. Weiner ,  Shmuel Edelstein ,  Zeev Mazor ,  David Ladkani ,  Benjamin Shalita ,  John A. Kanis

发明人： Mordecai Popovtzer ,  Ben Z. Weiner ,  Shmuel Edelstein ,  Zeev Mazor ,  David Ladkani ,  Benjamin Shalita ,  John A. Kanis

IPC分类号： A61K31/59 ,  A61P3/00 ,  A61P13/02 ,  A61P15/00 ,  A61P43/00

CPC分类号： A61K31/59

摘要： A method and composition for an improved treatment of human renal osteodystrophy, comprising the administration of 6-40 mcg/d (micrograms per day) of 24,25(OH).sub.2 D.sub.3 in combination with amounts of 1-alpha(OH)D.sub. 3 or 1,25(OH).sub.2 D.sub.3 or DHT.sub.2, which will maintain in the serum of patients the calcium concentration at 10-11 mg/dl (milligrams per deciliter) and the phosphate concentration at 5.5-6.0 mg/dl (milligrams per deciliter) and the numerical multiplication product of calcium x phosphate not more than 60-65.