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公开(公告)号：US08697131B2
公开(公告)日：2014-04-15
申请号：US13138389
申请日：2010-02-11
CPC分类号： A61K9/14 , A61K9/1635 , A61K9/1652
摘要： Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.
摘要翻译： 通过将溶剂 - 非溶剂沉淀物与原位喷雾干燥方法组合来制备小粒径的药物药物颗粒。 将药物分散在水混溶性溶剂，特别是乙醇中，并在进料管线中在压力下加热到高于溶剂沸点直到药物溶解。 这种溶液在气体渗透的微反应器中作为细水射流与细水射流碰撞，并且所产生的细雾迅速蒸发。 有机溶剂首先蒸发，然后蒸发。 水可能含有表面改性剂。
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公开(公告)号：US08852644B2
公开(公告)日：2014-10-07
申请号：US13636347
申请日：2011-03-21
CPC分类号： B01J2/06 , B01J2/04 , Y10S977/773 , Y10T428/2982
摘要： The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation and self-organization processes in microjet reactors, a solvent, which contains at least one target molecule, and a nonsolvent being mixed as jets that collide with each other in a microjet reactor at defined pressures and flow rates and thereby effect very rapid precipitation, co-precipitation or a chemical reaction, during the course of which microparticles or nanoparticles are formed. In order to create such a method, with which the particle size of the resulting microparticles or nanoparticles can be specifically controlled, it is proposed within the scope of the invention that particle size be controlled by the temperature at which the solvent and nonsolvent collide, the flow rate of the solvent and the nonsolvent and/or the amount of gas, smaller particle sizes being obtained at lower temperatures, at high solvent and nonsolvent flow rates and/or in the complete absence of gas.
摘要翻译： 本发明涉及通过微喷射反应器中的受控沉淀，共沉淀和自组装方法生产水溶性和水不溶性物质的微粒或纳米颗粒的方法，含有至少一种靶分子的溶剂和非溶剂 作为在微喷射反应器中以确定的压力和流速相互碰撞的喷射器混合，从而在其形成微粒或纳米颗粒的过程中实现非常快速的沉淀，共沉淀或化学反应。 为了形成这样的方法，可以特别地控制所得到的微粒或纳米颗粒的粒度，在本发明的范围内，通过溶剂和非溶剂碰撞的温度来控制粒度， 溶剂和非溶剂的流速和/或气体量，在较低温度下，在高溶剂和非溶剂流速下和/或完全不存在气体时获得的较小颗粒尺寸。
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公开(公告)号：US20130012551A1
公开(公告)日：2013-01-10
申请号：US13636347
申请日：2011-03-21
IPC分类号： B01J19/26 , A61K31/235 , A61K31/44 , B82Y5/00
CPC分类号： B01J2/06 , B01J2/04 , Y10S977/773 , Y10T428/2982
摘要： The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation and self-organization processes in microjet reactors, a solvent, which contains at least one target molecule, and a nonsolvent being mixed as jets that collide with each other in a microjet reactor at defined pressures and flow rates and thereby effect very rapid precipitation, co-precipitation or a chemical reaction, during the course of which microparticles or nanoparticles are formed. In order to create such a method, with which the particle size of the resulting microparticles or nanoparticles can be specifically controlled, it is proposed within the scope of the invention that particle size be controlled by the temperature at which the solvent and nonsolvent collide, the flow rate of the solvent and the nonsolvent and/or the amount of gas, smaller particle sizes being obtained at lower temperatures, at high solvent and nonsolvent flow rates and/or in the complete absence of gas.
摘要翻译： 本发明涉及一种通过微喷射反应器中控制沉淀，共沉淀和自组装过程生产水溶性和水不溶性物质的微粒或纳米颗粒的方法，含有至少一种靶分子的溶剂和非溶剂 作为在微喷射反应器中以确定的压力和流速相互碰撞的喷射器混合，从而在其形成微粒或纳米颗粒的过程中实现非常快速的沉淀，共沉淀或化学反应。 为了形成这样的方法，可以特别地控制所得到的微粒或纳米颗粒的粒度，在本发明的范围内，通过溶剂和非溶剂碰撞的温度来控制粒度， 溶剂和非溶剂的流速和/或气体量，在较低温度下，在高溶剂和非溶剂流速下和/或完全不存在气体时获得的较小颗粒尺寸。
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4.发明申请公开(公告)号：US20110294770A1
公开(公告)日：2011-12-01
申请号：US13138389
申请日：2010-02-11
IPC分类号： A61K31/58 , A61P3/10 , A61P5/24 , A61K31/403
CPC分类号： A61K9/14 , A61K9/1635 , A61K9/1652
摘要： Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.
摘要翻译： 通过将溶剂 - 非溶剂沉淀物与原位喷雾干燥方法组合来制备小粒径的药物药物颗粒。 将药物分散在水混溶性溶剂，特别是乙醇中，并在进料管线中在压力下加热到高于溶剂沸点直到药物溶解。 这种溶液在气体渗透的微反应器中作为细水射流与细水射流碰撞，并且所产生的细雾迅速蒸发。 有机溶剂首先蒸发，然后蒸发。 水可能含有表面改性剂。
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