公开(公告)号：US07241782B1

公开(公告)日：2007-07-10

申请号：US10276881

申请日：2000-09-25

申请人： Darko Filić ,  Miljenko Dumić ,  Bo{hacek over (z)}ena Klepić ,  Aleksandar Danilovski ,  Marijan Tudja

发明人： Darko Filić ,  Miljenko Dumić ,  Bo{hacek over (z)}ena Klepić ,  Aleksandar Danilovski ,  Marijan Tudja

IPC分类号： A61K31/44 ,  C07D213/70

CPC分类号： C07D213/74

摘要： The invention relates to a novel polymorph V of torasemide, to a process for its preparation, to its use as a raw material for the preparation of crystalline modifications I and III of torasemide, to amorphous torasemide modifications and to pharmaceutically acceptable salts of torasemide, to pharmaceutical forms containing the said novel polymorph V of torasemide as the active ingredient as well as to its use.

摘要翻译： 本发明涉及托拉塞米的新型多晶型V，其制备方法，其用作制备托拉塞米的晶体修饰I和III的原料，其用于无定形托拉塞米改性和托拉塞米的药学上可接受的盐， 含有所述新型多晶型V的托拉塞米作为活性成分的药物形式及其用途。

公开(公告)号：US06833379B2

公开(公告)日：2004-12-21

申请号：US10096277

申请日：2002-03-13

申请人： Darko Filić ,  Miljenko Dumić ,  Aleksandar Danilovski ,  Bo{hacek over (z)}ena Klepić ,  Ines Fistrić ,  Marina Ore{hacek over (s)}ić ,  Jasna Horvat Mikul{hacek over (c)}ić

发明人： Darko Filić ,  Miljenko Dumić ,  Aleksandar Danilovski ,  Bo{hacek over (z)}ena Klepić ,  Ines Fistrić ,  Marina Ore{hacek over (s)}ić ,  Jasna Horvat Mikul{hacek over (c)}ić

IPC分类号： A61K3147

CPC分类号： A61K31/44 ,  C07D213/53 ,  C07D213/71 ,  C07D213/74

摘要： The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use as a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.