公开(公告)号：US08568692B2

公开(公告)日：2013-10-29

申请号：US12847408

申请日：2010-07-30

申请人： Mark Banaszak-Holl ,  Joseph Wallace ,  Blake Erickson ,  Clifford M. Les ,  Bradford G. Orr

发明人： Mark Banaszak-Holl ,  Joseph Wallace ,  Blake Erickson ,  Clifford M. Les ,  Bradford G. Orr

IPC分类号： A61K49/00

CPC分类号： C12Q1/02

摘要： Methods and systems for diagnosing a bone disease related to collagen pathology in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference value is a quantitative collagen morphology value from the same type of bone sample obtained from a population of non-affected control subjects. The quantitative collagen morphology value of the subject's bone sample is compared to the reference value. If the collagen morphology value is altered versus the reference value, the subject is diagnosed as having a collagen related bone disease. The collagen morphology value can include mean fibril spacings and distributions of the fibril spacings taken from a subject's bone sample.

摘要翻译： 提供了用于诊断与受试者中的胶原病理学相关的骨疾病的方法和系统。 这些包括从受试者提供骨样品并确定骨样品的定量胶原形态学值。 从非受影响的对照受试者提供参考值，其中参考值是来自不受影响的对照受试者群体获得的相同类型的骨样品的定量胶原形态学值。 将受试者骨样本的定量胶原形态值与参考值进行比较。 如果相对于参考值改变胶原形态的值，则该受试者被诊断为具有胶原相关的骨病。 胶原形态值可以包括平均原纤维间隔和从受试者的骨样品取得的原纤维间隔的分布。

公开(公告)号：US20120232225A1

公开(公告)日：2012-09-13

申请号：US13392421

申请日：2010-07-23

申请人： James R. Baker, JR. ,  Mark M. Banaszak Holl ,  Douglas Gurnett Mullen ,  Bradford G. Orr ,  Ankur Desai ,  Leonard M. Sander ,  Jack Neel Waddell

发明人： James R. Baker, JR. ,  Mark M. Banaszak Holl ,  Douglas Gurnett Mullen ,  Bradford G. Orr ,  Ankur Desai ,  Leonard M. Sander ,  Jack Neel Waddell

IPC分类号： C08G63/91

CPC分类号： C08G83/004

摘要： The present invention relates to novel methods of synthesis and isolation of dendrimer systems. In particular, the present invention is directed to novel dendrimer conjugates with defined and limited numbers of ligand conjugates and high levels of structural uniformity, methods of synthesizing the same, compositions comprising the conjugates, as well systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)).

摘要翻译： 本发明涉及树枝状大分子体系的合成和分离的新方法。 特别地，本发明涉及具有限定数量和限定数量的配体缀合物和高水平结构均匀性的新型树状聚合物缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如， 诊断和/或治疗设置（例如，用于递送治疗剂，成像和/或靶向剂（例如，在疾病（例如，癌症）诊断和/或治疗，疼痛治疗等中））。

公开(公告)号：US20110189716A1

公开(公告)日：2011-08-04

申请号：US12847408

申请日：2010-07-30

申请人： Mark Banaszak-Holl ,  Joseph Wallace ,  Blake Erickson ,  Clifford M. Les ,  Bradford G. Orr

发明人： Mark Banaszak-Holl ,  Joseph Wallace ,  Blake Erickson ,  Clifford M. Les ,  Bradford G. Orr

IPC分类号： C12Q1/02

CPC分类号： C12Q1/02

摘要： Methods and systems for diagnosing a bone disease related to collagen pathology in a subject are provided. These include providing a bone sample from the subject and determining a quantitative collagen morphology value of the bone sample. A reference value is provided from a non-affected control subject where the reference value is a quantitative collagen morphology value from the same type of bone sample obtained from a population of non-affected control subjects. The quantitative collagen morphology value of the subject's bone sample is compared to the reference value. If the collagen morphology value is altered versus the reference value, the subject is diagnosed as having a collagen related bone disease. The collagen morphology value can include mean fibril spacings and distributions of the fibril spacings taken from a subject's bone sample.

摘要翻译： 提供了用于诊断与受试者中的胶原病理学相关的骨疾病的方法和系统。 这些包括从受试者提供骨样品并确定骨样品的定量胶原形态学值。 从非受影响的对照受试者提供参考值，其中参考值是来自不受影响的对照受试者群体获得的相同类型的骨样品的定量胶原形态学值。 将受试者骨样本的定量胶原形态值与参考值进行比较。 如果相对于参考值改变胶原形态的值，则该受试者被诊断为具有胶原相关的骨病。 胶原形态值可以包括平均原纤维间隔和从受试者的骨样品取得的原纤维间隔的分布。