公开(公告)号：US09675554B1

公开(公告)日：2017-06-13

申请号：US09719795

申请日：1999-06-16

申请人： Gregory Gregoriadis ,  Brahim Zadi ,  Pramukh N Jayasekera

发明人： Gregory Gregoriadis ,  Brahim Zadi ,  Pramukh N Jayasekera

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K9/1271 ,  A61K9/1278

摘要： Compositions of reagents are formed by forming empty liposomes, mixing the thus-formed liposomes with a sugar solution and a regent, then drying the mixture. The compositions will generally contain less than 10% w/v sucrose. Using this procedure small liposomes are formed with high entrapment efficiency. The process is useful in the production of pharmaceuticals.

公开(公告)号：US07025988B2

公开(公告)日：2006-04-11

申请号：US10182921

申请日：2001-01-31

申请人： Brahim Zadi

发明人： Brahim Zadi

IPC分类号： A61K9/127

CPC分类号： A61K9/1278 ,  A61K9/127

摘要： Liposomes containing lipophilic active ingredient are produced by dehydrating a mixture of liposomes, lipophilic active ingredient and sugar, usually followed by a rehydration step to form dehydration-rehydration vesicles. The lipophilic drug is suitably paclitaxel. The sugar is usually sucrose. The liposome forming compounds preferably include cholesterol and phosphatidylcholine, and optionally an anionic lipid. The ratio of sugar:lipid is preferably at least 5:1 w/w. The ratio of lipid:drug is preferably (up to 10):1 w/w.

摘要翻译： 通过将脂质体，亲脂性活性成分和糖的混合物脱水，通常进行再水化步骤以形成脱水 - 再水化泡囊来制备含有亲脂性活性成分的脂质体。 亲脂性药物适宜为紫杉醇。 糖通常是蔗糖。 形成脂质体的化合物优选包括胆固醇和磷脂酰胆碱，和任选的阴离子脂质。 糖：脂质的比例优选为至少5:1w / w。 脂质：药物的比例优选为（至多10）：1w / w。