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公开(公告)号:US07026328B2
公开(公告)日:2006-04-11
申请号:US10447308
申请日:2003-05-27
申请人: Andrei W. Konradi , Christopher M. Semko , Ying-zi Xu , Frank Stappenbeck , Brian P. Stupl , Jenifer L. Smith , Michael A. Pleiss , Eugene D. Thorsett
发明人: Andrei W. Konradi , Christopher M. Semko , Ying-zi Xu , Frank Stappenbeck , Brian P. Stupl , Jenifer L. Smith , Michael A. Pleiss , Eugene D. Thorsett
IPC分类号: C07D239/50 , A61K31/505
CPC分类号: C07D401/12 , C07D239/50 , C07D403/12
摘要: Disclosed are compounds which bind α4 integrins, preferably VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by α4 integrins, preferably VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.