Combination therapy for treating or managing acute myelocytic leukemia
    1.
    发明申请
    Combination therapy for treating or managing acute myelocytic leukemia 审中-公开
    治疗或治疗急性骨髓性白血病的联合疗法

    公开(公告)号:US20070149571A1

    公开(公告)日:2007-06-28

    申请号:US11704665

    申请日:2007-02-09

    IPC分类号: A61K31/454

    摘要: The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective amount of one or more inhibitors of JNK in combination with the administration of an effective amount of one or more other agents useful for cancer therapy. The invention also provides pharmaceutical compositions comprising one or more inhibitors of JNK in combination with one or more other agents useful for cancer therapy. In particular, the invention is directed to methods of treatment and prevention of cancer by the administration of an effective amount of one or more inhibitors of JNK in combination with standard and experimental chemotherapies, hormonal therapies, bone marrow transplants, stem cell replacement therapies, biological therapies/immunotherapies and/or radiation therapies for treatment or prevention of cancer. Also included are methods of treatment of cancer by the administration of one or more inhibitors of JNK in combination with surgery, alone or in further combination with standard and experimental chemotherapies, hormonal therapies, bone marrow transplants, stem cell replacement therapies, biological therapies/immunotherapies and/or radiation therapies.

    摘要翻译: 本发明涉及设计用于治疗,管理或预防癌症的方法和组合物。 本发明的方法包括施用有效量的一种或多种JNK抑制剂与施用有效量的一种或多种其它可用于癌症治疗的试剂的组合。 本发明还提供包含一种或多种JNK抑制剂与一种或多种其它可用于癌症治疗的试剂组合的药物组合物。 特别地,本发明涉及通过给予有效量的一种或多种JNK抑制剂与标准和实验化学疗法,激素疗法,骨髓移植物,干细胞替代疗法,生物学方法,治疗和预防癌症的方法 用于治疗或预防癌症的治疗/免疫治疗和/或放射疗法。 还包括通过单独或与标准和实验化疗,激素治疗,骨髓移植,干细胞替代疗法,生物疗法/免疫疗法单独或进一步组合的一种或多种JNK抑制剂的给药来治疗癌症的方法 和/或放射疗法。