专利检索 ap:"CENTRE HOSPITALER UNIVERSITAIRE DE NANTES" 第 1 页

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发明申请
METHODS FOR INCREASING EXPANSION AND IMMUNOSUPPRESSIVE CAPACITY OF A POPULATION OF CD8+CD45RCLOW/- TREGS 有权

公开(公告)号：US20210147801A1

公开(公告)日：2021-05-20

申请号：US16630098

申请日：2018-07-12

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE NANTES , CENTRE HOSPITALER UNIVERSITAIRE DE NANTES

发明人： Carole GUILLONNEAU , Ignacio ANEGON , Séverine BEZIE

IPC分类号： C12N5/0783 , A61K35/17 , A61P37/06

摘要： A population of highly suppressive human CD8+CD45RClow/− Tregs is characterized by expressing Foxp3 and producing IFNγ, IL-10, IL-34 and TGFβ to mediate their suppressive activity. Accordingly, methods capable of increasing expansion and immunosuppressive capacity of such a population of CD8+CD45RClow/− Tregs are highly desirable for therapeutic purposes. Rapamycin has been shown to increase the expansion and immunosuppressive capacities of the population of CD8+CD45RClow/− Tregs. Accordingly, the method of increasing expansion and immunosuppressive capacity of a population of CD8+CD45RClow/− Tregs includes culturing the population of CD8+CD45RClow/− Tregs in presence of a rapamycin compound.