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公开(公告)号：US20240287039A1
公开(公告)日：2024-08-29
申请号：US18390494
申请日：2023-12-20
Inventor： Richard E. LEE , Rajendra P. TANGALLAPALLY , Charles O. ROCK , Suzanne JACKOWSKI , Anne V. EDWARDS , Mi Kyung YUN , Chitra SUBRAMANIAN , Robert ZAMBONI , T. Jagadeeswar REDDY
IPC: C07D403/04 , A61K31/197
CPC classification number: C07D403/04 , A61K31/197
Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US11547709B2
公开(公告)日：2023-01-10
申请号：US16957996
申请日：2018-12-26
Inventor： Suzanne Jackowski , Charles O. Rock , Richard E. Lee , Lalit Kumar Sharma , Mi Kyung Yun , Chitra Subramanian , Rajendra P. Tangallapally , Anne V. Edwards , Robert Zamboni , T. Jagadeeswar Reddy , Jiuyu Liu
IPC: A61K31/501 , A61P3/00 , A61K31/197 , A61K31/205
Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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Patent Agency Ranking
公开(公告)号：US11891378B2
公开(公告)日：2024-02-06
申请号：US16958022
申请日：2018-12-26
Inventor： Richard E. Lee , Rajendra P. Tangallapally , Charles O. Rock , Suzanne Jackowski , Anne V. Edwards , Mi Kyung Yun , Chitra Subramanian , Robert Zamboni , T. Jagadeeswar Reddy
IPC: C07D403/04 , A61K31/197
CPC classification number: C07D403/04 , A61K31/197
Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20210061788A1
公开(公告)日：2021-03-04
申请号：US16958022
申请日：2018-12-26
Inventor： Richard E. LEE , Rajendra P. TANGALLAPALLY , Charles O. ROCK , Suzanne JACKOWSKI , Anne V. EDWARDS , Mi Kyung YUN , Chitra SUBRAMANIAN , Robert ZAMBONI , T. Jagadeeswar REDDY
IPC: C07D403/04
Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20250090526A1
公开(公告)日：2025-03-20
申请号：US18642382
申请日：2024-04-22
Inventor： Suzanne JACKOWSKI , Charles O. ROCK , Richard E. LEE , Lalit Kumar SHARMA , Mi Kyung YUN , Chitra SUBRAMANIAN , Rajendra P. TANGALLAPALLY , Anne V. EDWARDS , Robert ZAMBONI , T. Jagadeeswar REDDY , Jiuyu LIU
IPC: A61K31/501 , A61K31/197 , A61K31/205 , A61P3/00
Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20230321092A1
公开(公告)日：2023-10-12
申请号：US18076044
申请日：2022-12-06
Inventor： Suzanne JACKOWSKI , Charles O. ROCK , Richard E. LEE , Lalit Kumar SHARMA , Mi Kyung YUN , Chitra SUBRAMANIAN , Rajendra P. TANGALLAPALLY , Anne V. EDWARDS , Robert ZAMBONI , T. Jagadeeswar REDDY , Jiuyu LIU
IPC: A61K31/501 , A61P3/00 , A61K31/197 , A61K31/205
CPC classification number: A61K31/501 , A61P3/00 , A61K31/197 , A61K31/205
Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20210023081A1
公开(公告)日：2021-01-28
申请号：US16957996
申请日：2018-12-26
Inventor： Suzanne JACKOWSKI , Charles O. ROCK , Richard E. LEE , Lalit Kumar SHARMA , Mi Kyung YUN , Chitra SUBRAMANIAN , Rajendra P. TANGALLAPALLY , Anne V. EDWARDS , Robert ZAMBONI , T. Jagadeeswar REDDY , Jiuyu LIU
IPC: A61K31/501 , A61K31/205 , A61K31/197 , A61P3/00
Abstract: The present disclosure relates to methods of treating a coenzyme A reduction, elevation, sequestration, toxicity, or redistribution (CASTOR) disease such as, for example, defects in fatty acid oxidation enzymes, methylmalonic acidemia, glutaric acidemia, propionic academia, and HMG-CoA lyase, via small molecule modulators of CoA levels. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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