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1.发明申请ANTI-TNF-ALPHA THERAPY FOR THE MUCOPOLYSACCHARIDOSES AND OTHER LYSOSOMAL DISORDERS 有权抗肿瘤坏死因子-α-阿尔法治疗脑血管病和其他淋巴细胞病公开(公告)号：US20140205584A1
公开(公告)日：2014-07-24
申请号：US14128411
申请日：2012-06-20
IPC分类号： A61K38/46 , A61K45/06 , A61K31/737
CPC分类号： A61K38/465 , A61K31/737 , A61K38/46 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of treating a subject with a lysosomal disorder, by administering an agent for enzyme replacement therapy and an agent for anti-TNF-α therapy; by administering a pentosan polysulfate therapy; or by administering a substrate reduction therapy and an anti-TNF-α therapy. The invention further relates to a method of reducing inflammatory cytokines in a subject with a lysosomal disorder that is being treated by enzyme replacement therapy, by administering an agent for anti-TNF-α therapy.
摘要翻译： 本发明涉及通过施用酶替代治疗剂和抗TNF-α治疗剂来治疗患有溶酶体病症的受试者的方法; 通过施用戊聚糖多硫酸盐治疗; 或通过施用底物还原疗法和抗TNF-α治疗。 本发明还涉及通过施用抗TNF-α治疗剂来减少患有通过酶替代疗法治疗的溶酶体病症的受试者的炎性细胞因子的方法。
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公开(公告)号：US20140287015A1
公开(公告)日：2014-09-25
申请号：US14343150
申请日：2012-09-07
CPC分类号： A61K38/50 , A61K35/32 , A61K38/1841 , C12N5/0655 , C12N2501/73 , C12N2506/1353 , C12Y305/01023 , A61K2300/00
摘要： The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders. Each of these methods involves treating a cell population with, and/or culturing a cell population in, a ceramidase
摘要翻译： 本发明涉及生产软骨细胞的方法，改善软骨细胞群体的表型，促进软骨形成，维持细胞群处于分化状态或增加分化状态的群体的细胞数，产生分化细胞群体， 并治疗某些疾病或病症。 这些方法中的每一种涉及用神经酰胺酶处理细胞群和/或培养细胞群
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公开(公告)号：US10350277B2
公开(公告)日：2019-07-16
申请号：US14343150
申请日：2012-09-07
摘要： The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders. Each of these methods involves treating a cell population with, and/or culturing a cell population in, a ceramidase.
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4.发明授权Anti-TNF-α therapy for the mucopolysaccharidoses and other lysosomal disorders 有权抗TNF-α治疗粘多糖贮积和其他溶酶体障碍公开(公告)号：US09155784B2
公开(公告)日：2015-10-13
申请号：US14128411
申请日：2012-06-20
IPC分类号： A61K31/737 , A61K38/46 , A61K45/06
CPC分类号： A61K38/465 , A61K31/737 , A61K38/46 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of treating a subject with a lysosomal disorder, by administering an agent for enzyme replacement therapy and an agent for anti-TNF-α therapy; by administering a pentosan polysulfate therapy; or by administering a substrate reduction therapy and an anti-TNF-α therapy. The invention further relates to a method of reducing inflammatory cytokines in a subject with a lysosomal disorder that is being treated by enzyme replacement therapy, by administering an agent for anti-TNF-α therapy.
摘要翻译： 本发明涉及通过施用酶替代治疗剂和抗TNF-α治疗剂来治疗患有溶酶体病症的受试者的方法; 通过施用戊聚糖多硫酸盐治疗; 或通过施用底物还原疗法和抗TNF-α治疗。 本发明还涉及通过施用抗TNF-α治疗剂来减少患有通过酶替代疗法治疗的溶酶体病症的受试者的炎性细胞因子的方法。
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