公开(公告)号：US20210061816A1

公开(公告)日：2021-03-04

申请号：US16902184

申请日：2020-06-15

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： C07D491/056 ,  C07D487/04 ,  C07D491/04 ,  C07D498/04 ,  A61K31/55

摘要： Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US10683304B2

公开(公告)日：2020-06-16

申请号：US16270470

申请日：2019-02-07

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： C07D491/04 ,  C07D487/04 ,  C07D498/04 ,  C07D491/056 ,  A61K31/55

摘要： Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US20180273511A1

公开(公告)日：2018-09-27

申请号：US15761995

申请日：2016-09-22

申请人： CAPELLA THERAPEUTICS, INC.

发明人： Yun Long

IPC分类号： C07D401/14 ,  A61P35/00 ,  C07D405/14

CPC分类号： C07D401/14 ,  A61K31/55 ,  A61P35/00 ,  C07D405/14 ,  C07D491/056 ,  C07D498/04

摘要： Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US11713322B2

公开(公告)日：2023-08-01

申请号：US17556626

申请日：2021-12-20

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： C07D498/04 ,  C07D491/056 ,  C07D487/04 ,  C07D491/04 ,  A61K31/55

CPC分类号： C07D491/056 ,  A61K31/55 ,  C07D487/04 ,  C07D491/04 ,  C07D498/04

摘要： Provided herein are benzimidazole derivatives, for example, or Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US20200216419A1

公开(公告)日：2020-07-09

申请号：US16799363

申请日：2020-02-24

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D498/04 ,  A61K31/55 ,  C07D491/056 ,  A61P35/00

摘要： Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US20180291012A1

公开(公告)日：2018-10-11

申请号：US16005490

申请日：2018-06-11

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： C07D409/14 ,  C07D403/12 ,  C07D403/14 ,  C07D223/04 ,  C07D405/14 ,  C07D401/14 ,  A61K31/55 ,  C07D403/04

摘要： Provided herein are benzimidazole derivatives, for example, of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US20230271938A1

公开(公告)日：2023-08-31

申请号：US17842073

申请日：2022-06-16

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D498/04 ,  A61K31/55 ,  C07D491/056 ,  A61P35/00

CPC分类号： C07D401/14 ,  A61K31/55 ,  A61P35/00 ,  C07D405/14 ,  C07D491/056 ,  C07D498/04

摘要： Provided herein are methods for treating, preventing, or ameliorating one or more symptoms of a condition, disorder, or disease mediated by a lipid kinase or a protein kinase with benzimidazoles, for example, of Formula I or II, and pharmaceutical compositions thereof. Also provided herein are benzimidazoles, and pharmaceutical compositions thereof; and methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US20220298167A1

公开(公告)日：2022-09-22

申请号：US17556626

申请日：2021-12-20

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： C07D491/056 ,  C07D487/04 ,  C07D491/04 ,  C07D498/04 ,  A61K31/55

摘要： Provided herein are benzimidazole derivatives, for example, or Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US10647707B2

公开(公告)日：2020-05-12

申请号：US16005490

申请日：2018-06-11

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： A61K31/4184 ,  C07D409/14 ,  C07D223/04 ,  A61K31/55 ,  C07D401/14 ,  C07D405/14 ,  C07D403/04 ,  C07D403/14 ,  C07D403/12

摘要： Provided herein are benzimidazole derivatives, for example, of Formula I, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.

公开(公告)号：US11242352B2

公开(公告)日：2022-02-08

申请号：US16902184

申请日：2020-06-15

申请人： Capella Therapeutics, Inc.

发明人： Yun Long

IPC分类号： C07D491/00 ,  C07D487/04 ,  C07D491/04 ,  C07D491/056 ,  C07D498/04 ,  A61K31/55

摘要： Provided herein are benzimidazole derivatives, for example, of Formula (I), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a proliferative disease.