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公开(公告)号：US09248313B2
公开(公告)日：2016-02-02
申请号：US13256767
申请日：2010-02-18
CPC分类号： A61N5/103 , A61N5/1038 , G06F19/00 , G06Q50/22
摘要： A therapy system includes a diagnostic image scanner (12) that acquires a diagnostic image of a target region to be treated. A planning processor (70) is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device (40) administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device (40) administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.
摘要翻译： 治疗系统包括：诊断图像扫描器（12），其获取待治疗的对象区域的诊断图像。 规划处理器（70）被配置为在治疗之前和期间基于患者特异性生物标志物生成患者特异性自适应放射治疗计划。 确定第一组患者特异性生物标志物，然后用于确定第一正常组织并发症概率（NTCP）模型和第一肿瘤控制概率（TCP）模型。 辐射治疗装置（40）使用基于第一NTCP模型和第一TCP模型的协议向目标区域施加第一剂量的辐射。 确定第二组患者特异性生物标志物。 使用第一组和第二组患者特异性生物标志物之间的关系来确定第二NTCP模型和第二TCP模型。 辐射治疗装置（40）使用基于第二NTCP模型和第二TCP模型的协议向目标区域施加第二剂量的辐射。
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公开(公告)号：US08320519B2
公开(公告)日：2012-11-27
申请号：US12305492
申请日：2007-06-13
IPC分类号： A61B6/00
CPC分类号： A61B6/5282 , A61B6/032 , A61B6/4014 , A61B6/483 , A61B6/508 , G01T1/2985
摘要： A tomographic apparatus (10) includes at least two x-ray sources (16) that are concurrently driven with different switching patterns to generate uniquely encoded radiation. The tomographic apparatus (10) further includes at least two detectors (20) that each detect primary radiation emitted by its corresponding one of the at least two x-ray sources (16) and cross scatter radiation from at least one of the other at least two x-ray sources (16). Each of the at least two detectors (20) produces an aggregate signal representative of the detected primary and cross scatter radiation. The tomographic apparatus (10) further includes a decoupler (30) which, based on the different switching patterns, identifies at least one signal corresponding to at least one of the at least two x-ray sources (16) within the aggregate signal and associates the identified signal with its corresponding x-ray source (16).
摘要翻译： 断层摄影装置（10）包括至少两个x射线源（16），它们以不同的切换模式同时驱动以产生唯一编码的辐射。 断层摄影装置（10）还包括至少两个检测器（20），每个检测器（20）检测由其至少两个X射线源（16）中的相应一个发射的主要辐射，并且至少另外至少另外一个的交叉散射辐射 两个x射线源（16）。 所述至少两个检测器（20）中的每个检测器（20）产生表示检测到的主要和交叉散射辐射的聚集信号。 断层摄影装置（10）还包括解耦器（30），其基于不同的切换模式，识别对应于聚合信号内的至少两个x射线源（16）中的至少一个的至少一个信号和关联 所识别的信号与其相应的x射线源（16）。
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公开(公告)号：US20110311019A1
公开(公告)日：2011-12-22
申请号：US12305492
申请日：2007-06-13
IPC分类号： A61B6/03
CPC分类号： A61B6/5282 , A61B6/032 , A61B6/4014 , A61B6/483 , A61B6/508 , G01T1/2985
摘要： A tomographic apparatus (10) includes at least two x-ray sources (16) that are concurrently driven with different switching patterns to generate uniquely encoded radiation. The tomographic apparatus (10) further includes at least two detectors (20) that each detect primary radiation emitted by its corresponding one of the at least two x-ray sources (16) and cross scatter radiation from at least one of the other at least two x-ray sources (16). Each of the at least two detectors (20) produces an aggregate signal representative of the detected primary and cross scatter radiation. The tomographic apparatus (10) further includes a decoupler (30) which, based on the different switching patterns, identifies at least one signal corresponding to at least one of the at least two x-ray sources (16) within the aggregate signal and associates the identified signal with its corresponding x-ray source (16).
摘要翻译： 断层摄影装置（10）包括至少两个x射线源（16），它们以不同的切换模式同时驱动以产生唯一编码的辐射。 断层摄影装置（10）还包括至少两个检测器（20），每个检测器（20）检测由其至少两个X射线源（16）中的相应一个发射的主要辐射，并且至少另外至少另外一个的交叉散射辐射 两个x射线源（16）。 所述至少两个检测器（20）中的每个检测器（20）产生表示检测到的主要和交叉散射辐射的聚集信号。 断层摄影装置（10）还包括解耦器（30），其基于不同的切换模式，识别对应于聚合信号内的至少两个x射线源（16）中的至少一个的至少一个信号和关联 所识别的信号与其相应的X射线源（16）。
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公开(公告)号：US20120004492A1
公开(公告)日：2012-01-05
申请号：US13256767
申请日：2010-02-18
CPC分类号： A61N5/103 , A61N5/1038 , G06F19/00 , G06Q50/22
摘要： A therapy system includes a diagnostic image scanner (12) that acquires a diagnostic image of a target region to be treated. A planning processor (70) is configured to generate a patient specific adaptive radiation therapy plan based on patient specific biomarkers before and during therapy. A first set of patient specific biomarkers is determined then used for the determination of a first normal tissue complication probability (NTCP) model and a first tumor control probability (TCP) model. A radiation therapy device (40) administers a first dose of radiation to the target region with a protocol based on the first NTCP model and the first TCP model. A second set of patient specific biomarkers is determined. A relationship between the first set and second set of patient specific biomarkers is used to determine a second NTCP model and a second TCP model. The radiation therapy device (40) administers a second dose of radiation to the target region with a protocol based on the second NTCP model and second TCP model.
摘要翻译： 治疗系统包括：诊断图像扫描器（12），其获取待治疗的对象区域的诊断图像。 规划处理器（70）被配置为在治疗之前和期间基于患者特异性生物标志物生成患者特异性自适应放射治疗计划。 确定第一组患者特异性生物标志物，然后用于确定第一正常组织并发症概率（NTCP）模型和第一肿瘤控制概率（TCP）模型。 辐射治疗装置（40）使用基于第一NTCP模型和第一TCP模型的协议向目标区域施加第一剂量的辐射。 确定第二组患者特异性生物标志物。 使用第一组和第二组患者特异性生物标志物之间的关系来确定第二NTCP模型和第二TCP模型。 辐射治疗装置（40）使用基于第二NTCP模型和第二TCP模型的协议向目标区域施加第二剂量的辐射。
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