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公开(公告)号：US09205046B2
公开(公告)日：2015-12-08
申请号：US12778879
申请日：2010-05-12
IPC分类号： A61K31/717 , A61K9/10 , A61K9/127 , A61P25/00 , A61P41/00 , A61K9/00 , A61K38/18 , A61K47/36 , A61K47/38
CPC分类号： A61K9/0024 , A61K9/0095 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K47/36 , A61K47/38
摘要： The present invention relates to a composite hydrogel comprising a blend of an aqueous solution of an anionic polysaccharide or a derivative thereof, such as hyaluronan (also commonly referred to as hyaluronic acid) or a derivative thereof and an aqueous solution of methylcellulose or another water soluble cellulose derivative thereof, having dispersed polymeric particles, such as polymeric hydrophobic particles therein selected from micro particles and nanoparticles, and wherein the stability of the hydrogel is enhanced relative to the stability of the hydrogel alone. The polymeric particles may contain at least one therapeutic agent, in which case each therapeutic agent exhibits a linear sustained release rate that can be tuned or altered by selecting the appropriate polymer formulation of the micro particles and/or nanoparticles. The composite may be injectable, and in the absence of a therapeutic agent may be used as a bulking agent for reconstructive and cosmetic surgery or may act as a platform for subsequent delivery of therapeutic agents.
摘要翻译： 本发明涉及一种复合水凝胶，其包含阴离子多糖或其衍生物的水溶液如透明质酸（也通常称为透明质酸）或其衍生物和甲基纤维素水溶液或其它水溶性的共混物 纤维素衍生物，其具有分散的聚合物颗粒，例如其中选自微粒和纳米颗粒的聚合疏水颗粒，并且其中相对于单独的水凝胶的稳定性，水凝胶的稳定性得到增强。 聚合物颗粒可以含有至少一种治疗剂，在这种情况下，每种治疗剂都显示线性缓释速率，可通过选择微粒和/或纳米颗粒的合适的聚合物配方来调节或改变。 复合材料可以是可注射的，并且在没有治疗剂的情况下可以用作用于重建和整容手术的填充剂，或者可以用作随后递送治疗剂的平台。
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公开(公告)号：US20100285113A1
公开(公告)日：2010-11-11
申请号：US12778879
申请日：2010-05-12
IPC分类号： A61K31/717 , A61K9/10 , A61K9/127 , A61P25/00 , A61P41/00 , A61K38/18 , A61K31/7088 , A23L1/0534
CPC分类号： A61K9/0024 , A61K9/0095 , A61K38/1825 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K47/36 , A61K47/38
摘要： The present invention relates to a composite hydrogel comprising a blend of an aqueous solution of an anionic polysaccharide or a derivative thereof, such as hyaluronan (also commonly referred to as hyaluronic acid) or a derivative thereof and an aqueous solution of methylcellulose or another water soluble cellulose derivative thereof, having dispersed polymeric particles, such as polymeric hydrophobic particles therein selected from micro particles and nanoparticles, and wherein the stability of the hydrogel is enhanced relative to the stability of the hydrogel alone. The polymeric particles may contain at least one therapeutic agent, in which case each therapeutic agent exhibits a linear sustained release rate that can be tuned or altered by selecting the appropriate polymer formulation of the micro particles and/or nanoparticles. The composite may be injectable, and in the absence of a therapeutic agent may be used as a bulking agent for reconstructive and cosmetic surgery or may act as a platform for subsequent delivery of therapeutic agents.
摘要翻译： 本发明涉及一种复合水凝胶，其包含阴离子多糖或其衍生物的水溶液如透明质酸（也通常称为透明质酸）或其衍生物和甲基纤维素水溶液或其它水溶性的共混物 纤维素衍生物，其具有分散的聚合物颗粒，例如其中选自微粒和纳米颗粒的聚合疏水颗粒，并且其中相对于单独的水凝胶的稳定性，水凝胶的稳定性得到增强。 聚合物颗粒可以含有至少一种治疗剂，在这种情况下，每种治疗剂都显示线性缓释速率，可通过选择微粒和/或纳米颗粒的合适的聚合物配方来调节或改变。 复合材料可以是可注射的，并且在没有治疗剂的情况下可以用作用于重建和整容手术的填充剂，或者可以用作随后递送治疗剂的平台。
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