公开(公告)号：US06403791B1

公开(公告)日：2002-06-11

申请号：US09779963

申请日：2001-02-09

申请人： Hazel Joan Dyke ,  Alan Findlay Haughan ,  Christopher Lowe ,  George Martin Buckley ,  Richard John Davenport ,  Andrew Sharpe ,  Hannah Jayne Kendall ,  Verity Margaret Sabin ,  John Gary Montana ,  Catherine Louise Picken

发明人： Hazel Joan Dyke ,  Alan Findlay Haughan ,  Christopher Lowe ,  George Martin Buckley ,  Richard John Davenport ,  Andrew Sharpe ,  Hannah Jayne Kendall ,  Verity Margaret Sabin ,  John Gary Montana ,  Catherine Louise Picken

IPC分类号： C07D41304

CPC分类号： C07D413/12

摘要： A compound of the formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is C1-6 alkyl, cycloalkyl or NR4R5; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) NR4R5 is a nitrogen-containing heterocyclic ring; R6 is C1-3 alkyl; and R7 and R8, which are the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof.

摘要翻译： 式（Ⅳ）的化合物是任选被一个或多个氟取代的C 1-3烷基; R 2是C 1-6烷基，环烷基或NR 4 R 5; R 3是部分式（A），（B）或（B）的吡唑，咪唑或异恶唑基， C）NR4R5是含氮杂环; R6是C1-3烷基; 和R 7和R 8相同或不同，各自表示C 1-3烷基，卤素，CF 3或CN;或其药学上可接受的盐。