-
1.发明申请公开(公告)号：US20210380694A1
公开(公告)日：2021-12-09
申请号：US17290816
申请日：2019-11-06
申请人： William P. FORREST, JR. , Chakravarthy Nachu NARASIMHAN , Yogita KRISHNAMACHARI , Merck Sharp & Dohme Corp.
摘要： The invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. In some embodiments the formulations of the invention comprise between 5-250 mg/mL anti-PD-1 antibody, or antigen binding fragment thereof, a buffer, a stabilizer, a surfactant, and an antioxidant in the amounts specified herein. In particular embodiments, the anti-PD-1 antibody is pembrolizumab. The invention further provides methods for treating various cancers with stable formulations of the invention. In some embodiments of the methods of the invention, the formulations are administered to a subject by intravenous or subcutaneous administration.
-
2.发明授权Stable formulations of antibodies to human programmed death receptor PD-1 and related treatments 有权人类程序性死亡受体PD-1抗体的稳定配方及相关治疗公开(公告)号：US09220776B2
公开(公告)日：2015-12-29
申请号：US14008604
申请日：2012-03-29
CPC分类号： A61K39/39591 , A61K9/0019 , A61K9/19 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/2818 , C07K2317/24
摘要： The present invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The present invention further provides methods for treating various cancers and chronic infections with stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof.
摘要翻译： 本发明涉及针对人程序性死亡受体PD-1的抗体的稳定制剂或其抗原结合片段。 本发明还提供了用于针对人程序性死亡受体PD-1的抗体或其抗原结合片段的稳定制剂治疗各种癌症和慢性感染的方法。
-
3.发明申请STABLE FORMULATIONS OF ANTIBODIES TO HUMAN PROGRAMMED DEATH RECEPTOR PD-1 AND RELATED TREATMENTS 有权人类编程死亡受体PD-1和相关治疗剂的抗体的稳定制剂公开(公告)号：US20140234296A1
公开(公告)日：2014-08-21
申请号：US14008604
申请日：2012-03-29
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： A61K39/39591 , A61K9/0019 , A61K9/19 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/2818 , C07K2317/24
摘要： The present invention relates to stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof. The present invention further provides methods for treating various cancers and chronic infections with stable formulations of antibodies against human programmed death receptor PD-1, or antigen binding fragments thereof.
摘要翻译： 本发明涉及针对人程序性死亡受体PD-1的抗体的稳定制剂或其抗原结合片段。 本发明还提供了用于针对人程序性死亡受体PD-1的抗体或其抗原结合片段的稳定制剂治疗各种癌症和慢性感染的方法。
-
-
搜索结果
3 条记录 (耗时 0.01 秒)
