公开(公告)号：US20090302842A1

公开(公告)日：2009-12-10

申请号：US12300529

申请日：2007-05-10

申请人： Robert G. Griffin ,  Kan-Nian Hu ,  Timothy M. Swager ,  Changsik Song ,  Eric Dane

发明人： Robert G. Griffin ,  Kan-Nian Hu ,  Timothy M. Swager ,  Changsik Song ,  Eric Dane

IPC分类号： G01N24/08 ,  C07D401/02 ,  G01R33/44

CPC分类号： G01R33/281 ,  C07D401/12 ,  G01N24/087 ,  G01R33/465 ,  G01R33/5601 ,  Y10T436/24

摘要： The present invention provides methods for performing dynamic nuclear polarization using biradicals with a structure of formula (I) as described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a biradical of formula (I) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. The present invention also provides biradicals with a structure of formula (I) with the proviso that Q1 and Q2 are different when X1 and X2 are —O—. The present invention also provides methods for making biradicals with a structure of formula (IA) as described herein.

摘要翻译： 本发明提供使用如本文所述的式（I）结构的双基进行动态核极化的方法。 通常，所述方法包括（a）在磁场中提供冷冻样品，其中所述冷冻样品包括式（I）的双基和具有至少一个自旋半核的分析物; （b）通过用具有激发双向电子自旋跃迁的频率的辐射照射冷冻样品来使分析物的至少一个自旋半核偏振; （c）任选地熔化样品以产生熔融样品; 和（d）检测冷冻或熔融样品中分析物的至少一个旋转半核中的核自旋跃迁。 本发明还提供具有式（I）结构的双基，条件是当X 1和X 2为-O-时，Q 1和Q 2不同。 本发明还提供了如本文所述制备具有式（IA）结构的双基质的方法。

公开(公告)号：US07985594B2

公开(公告)日：2011-07-26

申请号：US12300529

申请日：2007-05-10

申请人： Robert G. Griffin ,  Kan-Nian Hu ,  Timothy M. Swager ,  Changsik Song ,  Eric Dane

发明人： Robert G. Griffin ,  Kan-Nian Hu ,  Timothy M. Swager ,  Changsik Song ,  Eric Dane

IPC分类号： G01N24/00 ,  C07D471/02 ,  C07D295/24

CPC分类号： G01R33/281 ,  C07D401/12 ,  G01N24/087 ,  G01R33/465 ,  G01R33/5601 ,  Y10T436/24

摘要： The present invention provides methods for performing dynamic nuclear polarization using biradicals with a structure of formula (I) as described herein. In general, the methods involve (a) providing a frozen sample in a magnetic field, wherein the frozen sample includes a biradical of formula (I) and an analyte with at least one spin half nucleus; (b) polarizing the at least one spin half nucleus of the analyte by irradiating the frozen sample with radiation having a frequency that excites electron spin transitions in the biradical; (c) optionally melting the sample to produce a molten sample; and (d) detecting nuclear spin transitions in the at least one spin half nucleus of the analyte in the frozen or molten sample. The present invention also provides biradicals with a structure of formula (I) with the proviso that Q1 and Q2 are different when X1 and X2 are —O—. The present invention also provides methods for making biradicals with a structure of formula (IA) as described herein.

摘要翻译： 本发明提供使用如本文所述的式（I）结构的双基进行动态核极化的方法。 通常，所述方法包括（a）在磁场中提供冷冻样品，其中所述冷冻样品包括式（I）的双基和具有至少一个自旋半核的分析物; （b）通过用具有激发双向电子自旋跃迁的频率的辐射照射冷冻样品来使分析物的至少一个自旋半核偏振; （c）任选地熔化样品以产生熔融样品; 和（d）检测冷冻或熔融样品中分析物的至少一个旋转半核中的核自旋跃迁。 本发明还提供具有式（I）结构的双基，条件是当X 1和X 2为-O-时，Q 1和Q 2不同。 本发明还提供了如本文所述制备具有式（IA）结构的双基质的方法。