公开(公告)号：US20080254041A1

公开(公告)日：2008-10-16

申请号：US10571496

申请日：2004-09-10

申请人： Steffen Ernst ,  Charlotte Georgi Jakobsen ,  Erwin Ludo Roggen

发明人： Steffen Ernst ,  Charlotte Georgi Jakobsen ,  Erwin Ludo Roggen

IPC分类号： A61K39/395

CPC分类号： C07K16/00 ,  A61K38/00 ,  C07K2317/34

摘要： The present invention relates to a method for selecting one or more immunotherapeutic preparation having improved properties as a vaccine against a target antigen, said method comprising raising antibodies against a group of candidate preparations and selecting one or more preparations which produces antibodies having higher affinity against the target antigen than does anti-bodies raised against at least one other preparation from the group. More particularly it relates to the need to provide recombinant allergens (Bet V 1) for SIT which have been modified by protein engineering.

摘要翻译： 本发明涉及一种选择一种或多种具有改善作为针对靶抗原的疫苗的性质的免疫治疗制剂的方法，所述方法包括针对一组候选制剂产生抗体，并选择一种或多种制备产生对 目标抗原比针对来自该组的至少一种其它制剂产生的抗体的抗原。 更具体地说，涉及为蛋白质工程改造的用于SIT的重组变应原（Bet V 1）的需要。