公开(公告)号：US06476204B1

公开(公告)日：2002-11-05

申请号：US09743790

申请日：2001-01-19

申请人： Sin-Hee Kim ,  Che-Youb Won ,  Chih-Chang Chu

发明人： Sin-Hee Kim ,  Che-Youb Won ,  Chih-Chang Chu

IPC分类号： C07H1510

CPC分类号： C08B37/0021 ,  A61K9/0014 ,  A61K47/36

摘要： Biodegradable hydrogels are formed by photocrosslinking dextran-maleic acid monoesters in which the average degree of substitution of each glucose unit of each &agr;-D-glucopyranosyl of dextran by maleic acid ranges from 0.60 to 1.6 and which have a weight average molecular weight ranging from 40,000 to 80,000 on a dextran basis. The hydrogels at pH 7 have maximum swelling ratios ranging from 500 to 1,500 percent. The hydrogels are characterized by increase in swelling ratio as average degree of substitution increases. The hydrogels are useful, for example, for drug delivery and solubility enhancers of drugs, as protective encapsulators of viruses used in gene therapy, and for conventional uses of hydrogels.

摘要翻译： 通过光学交联葡聚糖 - 马来酸单酯形成可生物降解的水凝胶，其中马来酸对葡聚糖的每个α-D-吡喃葡萄糖基的每个葡萄糖单元的平均取代度为0.60-1.6，重均分子量为40,000 以葡聚糖为基准，达到80,000。 pH7的水凝胶具有最大的膨胀比范围为500至1,500％。 水凝胶的特征在于平均取代度增加溶胀比增加。 水凝胶可用于例如药物递送和药物溶解度增强剂，作为用于基因治疗的病毒的保护性封装剂和用于水凝胶的常规用途。