公开(公告)号：US20070027156A1

公开(公告)日：2007-02-01

申请号：US10571271

申请日：2004-09-08

申请人： Hisao Nakai ,  Tetsuji Saito ,  Tetsuo Obitsu ,  Chiaki Minamoto ,  Mayuki Yoshida ,  Akihiro Kishi ,  Seishi Katsumata ,  Hideo Katayama

发明人： Hisao Nakai ,  Tetsuji Saito ,  Tetsuo Obitsu ,  Chiaki Minamoto ,  Mayuki Yoshida ,  Akihiro Kishi ,  Seishi Katsumata ,  Hideo Katayama

IPC分类号： A61K31/53 ,  A61K31/519 ,  C07D487/02

CPC分类号： C07D239/70 ,  C07D221/04 ,  C07D487/04 ,  C07D491/04

摘要： CRF antagonists comprising as an active ingredient, the compound of formula (I) wherein A ring is 5-6 membered mono-cyclic ring which may be substituted; B ring is 5-7 membered unsaturated mono-heterocyclic ring which may be contained another 1-2 of hetero atom(s) and substituted by another substituents; W1 and W2 is carbon atom or nitrogen atom; Z is NR3, oxygen atom, sulfur which may be oxidized or CR4R5; R1 is alkyl, alkenyl or alkynyl that may be substituted, amino which may be protected, hydroxyl which may be protected, S(O)nR6, COR7, or cyclic group which may be substituted; R2 is unsaturated cyclic group which may be substituted.

摘要翻译： CRF拮抗剂，其包含作为活性成分的式（I）化合物，其中A环是可被取代的5-6元单环; B环是5-7元不饱和单杂环，其可以含有另外1-2个杂原子并被另一个取代基取代; W 1和W 2是碳原子或氮原子; Z是NR 3，氧原子，可被氧化的硫或CR 4 R 5; R 1是可被取代的烷基，烯基或炔基，可被保护的氨基，可被保护的羟基，S（O）n R 6， COR 7或可以被取代的环状基团; R 2是可以被取代的不饱和环状基团。