公开(公告)号：US20120258552A1

公开(公告)日：2012-10-11

申请号：US13512385

申请日：2010-11-30

申请人： Hiroshi Takahashi ,  Yuki Takahashi ,  Chie Kaneko

发明人： Hiroshi Takahashi ,  Yuki Takahashi ,  Chie Kaneko

IPC分类号： G01N33/543

CPC分类号： G01N33/54313 ,  G01N33/531 ,  G01N33/54393

摘要： Provided is a homogenous measurement method using insoluble carrier particles that suppresses the matrix effect originating from the sample and also suppresses differences in measurement accuracy among different models of automated analyzers. Also provided is a measuring reagent for use in an automated analyzer. Inclusion of a silicone-based defoaming agent in the reagent reduces the matrix effect originating from the sample and reduces variability of measurement accuracy among different automated analyzers having differing specifications.

摘要翻译： 提供了使用不溶性载体颗粒的均匀测量方法，其抑制源自样品的基质效应，并且还抑制不同型号的自动分析仪之间的测量精度差异。 还提供了用于自动分析仪的测量试剂。 在试剂中包含硅氧烷消泡剂可降低源自样品的基质效应，并降低不同规格的不同自动分析仪之间测量精度的变异性。

公开(公告)号：US08940549B2

公开(公告)日：2015-01-27

申请号：US13258468

申请日：2010-06-30

申请人： Junichi Kondou ,  Mitsuaki Yamamoto ,  Chie Kaneko

发明人： Junichi Kondou ,  Mitsuaki Yamamoto ,  Chie Kaneko

IPC分类号： G01N33/546 ,  G01N33/68

CPC分类号： G01N33/6884 ,  G01N2333/4725 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/815

摘要： The present invention aims to provide an assay reagent and an assay for accurately measuring KL-6, in particular, an assay reagent and an assay for accurately measuring KL-6 in samples containing a rheumatoid factor and/or a nonspecific substance other than the rheumatoid factor. KL-6 in samples that contain a rheumatoid factor and/or a nonspecific substance other than the rheumatoid factor can be accurately measured using an immunoassay reagent comprising a solution at a pH of 4.0 to 5.5 containing a rheumatoid factor interference inhibitor and a solution of an insoluble carrier on which anti-KL-6 antibodies are immobilized.

摘要翻译： 本发明旨在提供一种测定试剂和用于精确测量KL-6，特别是测定试剂的测定法和用于在含有类风湿因子和/或除类风湿之外的非特异性物质的样品中精确测量KL-6的测定法 因子。 含有除类风湿因子以外的类风湿因子和/或非特异性物质的样品中的KL-6可以使用包含pH 4.0〜5.5的含有类风湿因子干扰抑制剂的溶液的免疫分析试剂和 抗KL-6抗体固定在其上的不溶性载体。

公开(公告)号：US20120040476A1

公开(公告)日：2012-02-16

申请号：US13258468

申请日：2010-06-30

申请人： Junichi Kondou ,  Mitsuaki Yamamoto ,  Chie Kaneko

发明人： Junichi Kondou ,  Mitsuaki Yamamoto ,  Chie Kaneko

IPC分类号： G01N33/566

CPC分类号： G01N33/6884 ,  G01N2333/4725 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/815

摘要： The present invention aims to provide an assay reagent and an assay for accurately measuring KL-6, in particular, an assay reagent and an assay for accurately measuring KL-6 in samples containing a rheumatoid factor and/or a nonspecific substance other than the rheumatoid factor. KL-6 in samples that contain a rheumatoid factor and/or a nonspecific substance other than the rheumatoid factor can be accurately measured using an immunoassay reagent comprising a solution at a pH of 4.0 to 5.5 containing a rheumatoid factor interference inhibitor and a solution of an insoluble carrier on which anti-KL-6 antibodies are immobilized.

摘要翻译： 本发明旨在提供一种测定试剂和用于精确测量KL-6，特别是测定试剂的测定法和用于在含有类风湿因子和/或除类风湿之外的非特异性物质的样品中精确测量KL-6的测定法 因子。 含有除类风湿因子以外的类风湿因子和/或非特异性物质的样品中的KL-6可以使用包含pH 4.0〜5.5的含有类风湿因子干扰抑制剂的溶液的免疫分析试剂和 抗KL-6抗体固定在其上的不溶性载体。