公开(公告)号：US20050113657A1

公开(公告)日：2005-05-26

申请号：US10721797

申请日：2003-11-26

申请人： Javier Alarcon ,  Kristin Weidemaier ,  Terry Amiss ,  John DeNuzzio ,  Christopher Herdman ,  Ross Jacobson ,  J. Pitner ,  Douglas Sherman

发明人： Javier Alarcon ,  Kristin Weidemaier ,  Terry Amiss ,  John DeNuzzio ,  Christopher Herdman ,  Ross Jacobson ,  J. Pitner ,  Douglas Sherman

IPC分类号： G01N21/77 ,  G01N33/542 ,  G01N33/543 ,  A61B5/00

CPC分类号： G01N21/7703 ,  G01N33/542 ,  G01N33/54373

摘要： A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. An optical conduit, preferably an optical fiber has an optical system at the proximal end of the optical conduit. A sensing element is attached to the distal end of the optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the sensing element includes reference groups with luminescence properties that are substantially unchanged by variations in the analyte concentrations.

摘要翻译： 公开了用于感测体内或体外的分析物浓度，特别是葡萄糖浓度的装置。 光导管，优选地，光导纤维在光导管的近端具有光学系统。 感测元件连接到光学导管的远端，并且包括适于与至少一种靶分析物结合的至少一种结合蛋白。 感测元件还包括至少一个报告基团，其随着分析物浓度的变化而发生发光变化。 可选地，感测元件包括具有通过分析物浓度的变化基本上不变的发光特性的参考组。

公开(公告)号：US20050113658A1

公开(公告)日：2005-05-26

申请号：US10967220

申请日：2004-10-19

申请人： Ross Jacobson ,  Kristin Weidemaier ,  Javier Alarcon ,  Christopher Herdman ,  Steven Keith

发明人： Ross Jacobson ,  Kristin Weidemaier ,  Javier Alarcon ,  Christopher Herdman ,  Steven Keith

IPC分类号： G01N21/77 ,  G01N33/542 ,  G01N33/543 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/6848 ,  A61B2560/0223 ,  G01N21/274 ,  G01N21/7703 ,  G01N33/542 ,  G01N33/54373 ,  G01N2021/7786 ,  G01N2201/1211

摘要： A device for sensing analyte concentration, and in particular glucose concentration, in vivo or in vitro is disclosed. A sensing element is attached to the distal end of an optical conduit, and comprises at least one binding protein adapted to bind with at least one target analyte. The sensing element further comprises at least one reporter group that undergoes a luminescence change with changing analyte concentrations. Optionally, the optical conduit and sensing element may be housed within a cannulated bevel.

摘要翻译： 公开了用于感测体内或体外的分析物浓度，特别是葡萄糖浓度的装置。 感测元件连接到光学导管的远端，并且包含适于与至少一种靶分析物结合的至少一种结合蛋白。 感测元件还包括至少一个报告基团，其随着分析物浓度的变化而发生发光变化。 可选地，光学导管和感测元件可以容纳在插管斜面内。