公开(公告)号：US5962432A

公开(公告)日：1999-10-05

申请号：US675555

申请日：1996-07-03

申请人： Karol La Croix ,  Christy Shaffer ,  Karla Jacobus ,  Janet Rideout ,  David Drutz

发明人： Karol La Croix ,  Christy Shaffer ,  Karla Jacobus ,  Janet Rideout ,  David Drutz

IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/70 ,  A61K47/02

CPC分类号： A61K9/0078 ,  A61K31/7072 ,  A61K47/02 ,  A61K9/08

摘要： A novel formulation of uridine 5'-triphosphate (UTP) for use in promoting increased mucociliary clearance of retained mucous secretions of the human airways, middle/inner ears, or sinuses is disclosed. The composition comprises UTP and aqueous solution having a therapeutic concentration between 5 and 35 mg/mL, which has controlled tonicity within the range of 250 to 1000 mOsM, pH-adjusted, having pH between 7.0 and 7.5; and sterile. The pH-adjusted formulation is capable of long-term storage in the refrigerated state, with a shelf life of up to 30 months if kept refrigerated at 5.degree. C. The formulation is delivered therapeutically either in a nebulized form using any of several commercially available nebulizers (e.g., jet, ultrasonic, etc.), or in liquid form.

摘要翻译： 公开了用于促进人气道，中耳/内耳或鼻窦的残留粘液分泌物的增加的粘膜纤毛清除的尿苷5'-三磷酸（UTP）的新制剂。 该组合物包含治疗浓度为5至35mg / mL的UTP和水溶液，其具有控制的张力度在250至1000mOsM的范围内，pH调节，pH在7.0至7.5之间; 无菌。 pH调节的制剂能够在冷藏状态下长期储存，如果在5℃下冷藏，保质期可长达30个月。使用几种商业上可得到的方法，以雾化形式递送该制剂 喷雾器（例如喷射，超声波等）或液体形式。