公开(公告)号：US07786330B2

公开(公告)日：2010-08-31

申请号：US12379553

申请日：2009-02-24

申请人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

发明人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

IPC分类号： C07C37/04 ,  C07C41/26

CPC分类号： C07C39/27 ,  C07C41/16 ,  C07C41/26 ,  C07C43/225 ,  C07C43/23

摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

公开(公告)号：US07928268B2

公开(公告)日：2011-04-19

申请号：US12805138

申请日：2010-07-14

申请人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

发明人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

IPC分类号： C07C41/01 ,  C07C43/205 ,  C07C39/24

CPC分类号： C07C41/16 ,  C07C37/00 ,  C07C37/02 ,  C07C41/01 ,  C07C41/26 ,  C07C43/23 ,  C07C39/27 ,  C07C43/225 ,  C07C39/245

摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

摘要翻译： 本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。 从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。 或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。 本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业化生产。

公开(公告)号：US20050234700A1

公开(公告)日：2005-10-20

申请号：US10824700

申请日：2004-04-15

申请人： Yongcheng Li ,  Yuping Wu ,  ChunShan Zhang

发明人： Yongcheng Li ,  Yuping Wu ,  ChunShan Zhang

IPC分类号： G06F17/28

CPC分类号： G06F17/2836

摘要： Under the present invention, a user will provide content to be translated to a translation engine. After making the translation, the user will be provided with the results and transaction process details specifying the context of the translation. Based on the context, the user can provide feedback regarding the quality of the translation. Then, based on the feedback, the translation resource used to make the translation can be updated.

摘要翻译： 在本发明中，用户将提供要翻译成翻译引擎的内容。 进行翻译后，将向用户提供指定翻译背景的结果和交易流程细节。 基于上下文，用户可以提供关于翻译质量的反馈。 然后，根据反馈，可以更新用于进行翻译的翻译资源。

公开(公告)号：US20090227817A1

公开(公告)日：2009-09-10

申请号：US12379553

申请日：2009-02-24

申请人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

发明人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

IPC分类号： C07C43/225 ,  C07C39/26

CPC分类号： C07C39/27 ,  C07C41/16 ,  C07C41/26 ,  C07C43/225 ,  C07C43/23

摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

摘要翻译： 本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。 从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。 或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。 本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业生产。

公开(公告)号：US20100286451A1

公开(公告)日：2010-11-11

申请号：US12805138

申请日：2010-07-14

申请人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

发明人： Mingjian Qiu ,  Wei Zhang ,  Zhaohui Chen ,  Chunshan Zhang ,  Yali Zhang

IPC分类号： C07C41/01 ,  C07C43/23

CPC分类号： C07C41/16 ,  C07C37/00 ,  C07C37/02 ,  C07C41/01 ,  C07C41/26 ,  C07C43/23 ,  C07C39/27 ,  C07C43/225 ,  C07C39/245

摘要： The present invention relates to a process for producing a 2-fluoro-6-halophenol as an intermediate; a process for producing a 2-alkoxy-3-fluorophenol and further a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; a second process for producing a 1,2-dialkoxy-3-fluorobenzene from the 2-fluoro-6-halophenol; and a 2-alkoxy-3-fluorophenol. The 2-fluoro-6-halophenol can be obtained using a 2-fluorophenol as a starting material and through a sulfonation reaction, a halogenation reaction, and a deprotection reaction. The 2-fluoro-6-halophenol is alkyl-etherified, and subsequently the halogen atom is converted into a hydroxyl group to obtain the 2-alkoxy-3-fluorophenol, which is further alkyl-etherified to thereby obtain the 1,2-dialkoxy-3-fluorobenzene. Alternatively, a 1,2-dialkoxy-3-fluorobenzene is also obtained by converting the halogen atom of the 2-fluoro-6-halophenol into a hydroxyl group to thereby form 3-fluorocatechol and subsequently alkyl-etherifying two hydroxyl groups thereof. The processes of the invention realize low production costs and high process yields, and thus are suitable for industrial production of a 1,2-dialkoxy-3-fluorobenzene.

摘要翻译： 本发明涉及作为中间体的2-氟-6-卤代苯酚的制造方法。 从2-氟-6-卤苯酚制备2-烷氧基-3-氟苯酚和1,2-二烷氧基-3-氟苯的方法; 从2-氟-6-卤代苯酚制备1,2-二烷氧基-3-氟苯的第二种方法; 和2-烷氧基-3-氟苯酚。 2-氟-6-卤代苯酚可以使用2-氟苯酚作为原料，通过磺化反应，卤化反应和脱保护反应得到。 2-氟-6-卤代苯酚被烷基醚化，随后将卤素原子转化为羟基，得到2-烷氧基-3-氟苯酚，进一步进行烷基醚化，从而得到1,2-二烷氧基 -3-氟苯。 或者，也可以通过将2-氟-6-卤代苯酚的卤素原子转化为羟基，从而形成3-氟邻苯二酚，然后将其两个羟基烷基醚化，得到1,2-二烷氧基-3-氟苯。 本发明的方法实现了低生产成本和高工艺产率，因此适用于1,2-二烷氧基-3-氟苯的工业生产。

公开(公告)号：US20070038710A1

公开(公告)日：2007-02-15

申请号：US11202888

申请日：2005-08-12

申请人： Yongcheng Li ,  Yuping Wu ,  Chunshan Zhang

发明人： Yongcheng Li ,  Yuping Wu ,  Chunshan Zhang

IPC分类号： G06F15/16

CPC分类号： G06Q10/107 ,  H04L51/08 ,  H04L51/22

摘要： Methods and computer program products for managing redundant email. According to one aspect of the invention, a determination is made as to whether a first email is contained in a second email. If the first email is contained in the second email, the first email is purged. Email attachments may be transferred from the first email to the second email, so that the attachments are not lost when the first email is purged.

摘要翻译： 用于管理冗余电子邮件的方法和计算机程序产品。 根据本发明的一个方面，确定第一邮件是否包含在第二邮件中。 如果第一封电子邮件包含在第二封电子邮件中，则会清除第一封电子邮件。 电子邮件附件可能会从第一封电子邮件转移到第二封电子邮件，以便在清除第一封电子邮件时附件不会丢失。